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NHS Direct has told ITV News they are investigating one "unexpected death" after a patient in the West Midlands contacted its 111 helpline service.
NHS Direct said of the nine contracts it is currently operating, it is investigating seven "potentially serious" incidents related to calls to the 111 service.
An "urgent" review of the NHS helpline in England will be carried out, after allegations that its service has been "chaotic" in some areas.
The 111 number has replaced NHS Direct, and emergency out of hours doctors' services in some parts of the country.
ITV News' Political Correspondent Libby Wiener reports:
- For urgent medical help calls but not a life-threatening 999 emergencies.
- Unlike 999, the service only offers access to health services, with the police operating on their own 101 non-emergency helpline.
- Replaces the services provided by NHS Direct, which will end in June.
- 111 operators are able to dispatch ambulances when appropriate.
NHS England will carry out an urgent review of the new 111 helpline following allegations its introduction has been chaotic and it has been close to meltdown, ITV News has learned.
The 111 number replaced NHS Direct and emergency out of hours doctor services in some areas.
Doctors have claimed that patients are being put at risk.
Watch ITV News at 6.30pm for more.
Latest ITV News reports
The new NHS 111 advice helpline is putting patients at risk, according to the first results from a survey of doctors.