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Clarence Mitchell, spokesman for the Kate and Gerry McCann, said: "Kate and Gerry remain very, very pleased with the work that Scotland Yard are doing and have been encouraged by Operation Grange from the day it began.
"Beyond that, they simply will not comment on what are police operational matters."
Detective Chief Superintendent Hamish Campbell, who led a Metropolitan Police review of the six-year-old case, retired today as head of Scotland Yard’s homicide and serious crime command.
Speaking earlier this month, on the sixth anniversary of Madeleine McCann's disappearance, her parents Kate and Gerry, said they had not given up hope of finding their daughter.
Speaking on Daybreak, the couple said they have not lost hope that their daughter would be found and continue to campaign tirelessly for information on her whereabouts.
They believe the involvement of the Metropolitan Police now meant the hunt for their daughter was escalating, rather than grinding to a halt.
Mrs McCann said: "The search is very much ongoing. Nothing is slowing down, if anything I feel it's escalating with the work of the Met.
"And again it's just be vigilant, please still take your posters on holiday and don't forget about her, she's still missing.
"We haven't lost hope, our hope isn't any less than it was after the first 24, 48 hours."
Detectives reviewing the disappearance of Madeleine McCann have identified at least "a handful of people of interest" in connection with the case, Scotland Yard has confirmed.
A number of new potential suspects in the Madeleine McCann disappearance case have been identified, the London Evening Standard reports.
Scotland Yard investigators told the newspaper there are people "of interest" to the inquiry, after they carried out a review of the case.
Detective Chief Superintendent Hamish Campbell, who heads Scotland Yard's Homicide and Serious Crime Command, said a "good number" of individuals should be questioned and urged Portuguese police to investigate the new leads.
Madeleine went missing from an apartment in Praia de Luz, Portugal, in 2007 while her parents Kate and Gerry McCann were in a restaurant nearby.
Latest ITV News reports
Madeleine McCann detectives identified at least "a handful of people of interest" as part of a review of the case.
A timeline of some of the key events since Madeleine McCann disappeared in 2007 following reports suspects have been identified.