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The two prison collided with each other meaning it is not likely that this was an attempted prison break, Manchester Evening News reports citing the police.
Police did not expand on how the collision took place or whether murderer Dale Cregan was the injured prisoner.
The collision happened at a roundabout at the exit of Junction 31A on the M6 motorway northbound, police confirmed.
The junction is some five miles from Preston Crown Court, where the vans were headed.
Greater Manchester Police have confirmed that a collision took place between two prison vans, and that one prisoner and four prison officers were injured:
BBC Radio Manchester is reporting that a prison van transporting a man who murdered two police officers, Dale Cregan, has been involved in a collision.
There were no reports that any of the defendants in the van escaped or were injured.