Almost half of GPs say they can "no longer guarantee safe care" for their patients, while 85 percent of those questioned thought general practice was "in crisis", according to a recent poll of family doctors.
NHS England said it recognises that "a complex range of factors are causing pressures on GP services".
An NHS England spokesman said: "We want to explore with the profession how we can best enable GP practices to continue to provide a quality service and we look forward to working with the RCGP [Royal College of General Practitioners] to identify how best to achieve these goals.
"We are also working with Health Education England and other partners to look at how best to develop the primary care workforce. But it is essential that we also support primary care in making the most effective use of existing resources to improve quality of care".
The Royal College of General Practitioners (RCGP) said urgent action must be taken after a poll suggested almost half of GPs said they can "no longer guarantee safe care" for their patients.
Dr Clare Gerada, the chairwoman of the RCGP, said general practice is in "a state of crisis" and has called on officials to increase its budget.
"The results of this poll show that general practice is in a state of crisis and that urgent action must be taken to restore the ability of our family doctors to deliver safe patient care for all," she said.
"General practice is at the heart of the National Health Service, and if it starts to buckle, the whole of the health service starts to buckle and patient care in both primary and secondary care will suffer", Dr Gerada added.