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Wales will become the first country in the UK where people will be presumed to have consented for their organs to be donated unless they opt out - after Assembly Members tonight voted in favour of the new law by 43 votes to eight with two abstentions.
Wales could become the only UK country with an opt-out organ donation system if politicians vote to change the law.
Welsh Assembly members will meet in Cardiff to discuss the proposals later today.
ITV News Correspondent Richard Pallot reports.
As Wales prepares to pass a law which would make it the only UK country which has an opt-out organ donation system, ITV viewers have been giving their views via our Facebook page.
Kidney Wales Foundation has been campaigning for a new organ donation law for five years. The charity's chief executive Roy J Thomas told ITV News that the Human Transplantation Bill was a "progressive piece of legislation" that could bring a new culture of organ donation to Wales.
Dr Barry Morgan, Archbishop of Wales, told ITV News that he is in favour of organ donation, but feels the Human Transplantation Bill needs amending to take relatives' feelings into account.
Melanie Wager, who received a kidney in July 2010, has welcomed the proposed change to the law in Wales, saying:
The Kidney Wales Foundation, which was involved in the formulation of the 'opt-out' organ donor scheme in Wales, has stressed that family consent is vital.
Welsh health minister Mark Drakeford has argued that a new scheme that assumes consent for organ donation will increase the number of organs available for transplant.
He highlighted the fact that surveys have shown that a majority of Welsh people wish to be a donor.
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The Welsh Assembly has voted for a change in the law to try and save the lives of those who die while they wait for a transplant organ.
As Wales votes on changes to organ donation, ITV News speaks to those for and against the changes.