Wales will become the first country in the UK where people will be presumed to have consented for their organs to be donated unless they opt out - after Assembly Members tonight voted in favour of the new law by 43 votes to eight with two abstentions.
Wales could become the only UK country with an opt-out organ donation system if politicians vote to change the law.
Welsh Assembly members will meet in Cardiff to discuss the proposals later today.
ITV News Correspondent Richard Pallot reports.
As Wales prepares to pass a law which would make it the only UK country which has an opt-out organ donation system, ITV viewers have been giving their views via our Facebook page.
– MICHELLE BARGERY
"Personally myself being on dialysis for 28 years I feel organ donation is a fab thing I wonder if people would feel the same if attached to dialysis every other day for 4 hrs at a time."
– GENNI JUSTGENNI
"Better to opt out than opt in - too few organs around and most people seem to be happy to donate but don't get round to signing a consent form."
– CARLY CRISPIN
"Saving lives should not be optional but just a way of life."
Kidney Wales Foundation has been campaigning for a new organ donation law for five years. The charity's chief executive Roy J Thomas told ITV News that the Human Transplantation Bill was a "progressive piece of legislation" that could bring a new culture of organ donation to Wales.
Dr Barry Morgan, Archbishop of Wales, told ITV News that he is in favour of organ donation, but feels the Human Transplantation Bill needs amending to take relatives' feelings into account.
Melanie Wager, who received a kidney in July 2010, has welcomed the proposed change to the law in Wales, saying:
Waiting for an organ is an extremely difficult time for anyone - it is like being on death row and it seems as if you are being further punished for being ill.
Mentally, it is cruel for the patient and the caring family.
The Kidney Wales Foundation, which was involved in the formulation of the 'opt-out' organ donor scheme in Wales, has stressed that family consent is vital.
– Roy Thomas, chief executive, Kidney Wales Foundation
All Welsh residents will be able to register their personal wishes regarding organ donation ... If you do not opt-in, or opt-out, if you do nothing, you will have deemed to consent to organ donation ...
Deemed consent donation will not go ahead in the absence of any family member.
Kidney Wales believe the presence of the family is essential - both as a source of necessary information about the potential donor and in order to ensure that donation does not go ahead in the face of the deceased's known objection to organ donation.
Welsh health minister Mark Drakeford has argued that a new scheme that assumes consent for organ donation will increase the number of organs available for transplant.
He highlighted the fact that surveys have shown that a majority of Welsh people wish to be a donor.
– Mark Drakeford, health minister for wales
Deemed consent will bring about a cultural shift in the way donation proceeds in Wales.
It will alter the nature of some of the most difficult conversations that any family might face, and it will help to ensure that the wishes of that substantial majority of Welsh citizens who say, in survey after survey, that they would wish to be a donor, are put into practice in those very rare and special circumstances when donation is possible.