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Charity Breast Cancer Campaign said it hopes the health regulator's decision on a new breast cancer drug is "just a delay rather than the end of the line".
Baroness Delyth Morgan, the charity's chief executive, said:
Health regulator the National Institute for Health and Care Excellence (Nice) has decided a new drug to treat breast cancer "is not a cost-effective treatment option for the NHS".
Nice's chief executive Sir Andrew Dillon said: "We are committed to making sure the NHS provides the treatments that can make the greatest difference to people's lives.
"This means weighing up how well a treatment works and comparing it to similar treatments in the NHS, while also taking into account any associated side effects and the cost that the health service is being asked to pay.
"While the evidence presented ... suggested that everolimus with exemestane could delay the growth and spread of breast cancer by four to five months, the evidence did not allow the committee to establish how long everolimus could actually extend a person's life for, compared with exemestane alone.
"Using the evidence available, the committee concluded that everolimus is not a cost-effective treatment option for the NHS".
Breast cancer charities expressed their "utter disappointment" in the health regulator's decision that a new drug to treat breast cancer is ''not value for money''.
The latest draft guidance from the National Institute for Health and Care Excellence (Nice) recommended that the drug everolimus should not be available for widespread use on the NHS to treat a form of advanced breast cancer.
The Breakthrough Cancer charity said the announcement would come as a blow to the 1,500 women living in England and Wales who would be eligible for treatment.
The drug, also known as afinitor, is licensed for use in post-menopausal women with HER2 negative, hormone-receptor-positive advanced breast cancer if their disease has returned following a type of hormone therapy.
Manufacturers claim that the drug - if taken in combination with another medication - can extend the lives of patients for up to five months, however deemed that the drug was not "cost effective".