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Boris Johnson has reiterated his belief that London and the UK need to build a new airport in order to "remain competitive" against other ambitious cities.
The Mayor of London said a new airport should be located away from the Heathrow area which currently "blights the lives of hundreds of thousands of Londoners".
He suggested the area, with good transport links and infrastructure, could be used to generate 100,000 new homes.
Mr Johnson said: "Ambitious cities all over the world are already stealing a march on us and putting themselves in a position to eat London's breakfast, lunch and dinner by constructing mega airports that plug them directly into the global supply chains that we need to be part of.
"For London and the wider UK to remain competitive we have to build an airport capable of emulating that scale of growth."
The Mayor of London Boris Johnson has said a new airport on the Isle of Grain could be the answer to the UK's airport capacity issue.
Mr Johnson said a new four-runway airport, outlined by architect Lord Foster, on the Isle of Grain on the Hoo Peninsula in Kent should be considered.
The Mayor has previously voiced his support for an airport on an artificial island - dubbed "Boris Island" - on the outer Thames Estuary.
Johnson, who ruled out expanding Heathrow airport, also proposed a four-runway hub at Stansted in Essex - significantly expanding the existing airport.
The Mayor, who will submit the plans to the Government appointed Airport Commission led by Sir Howard Davies later this week, said the new hub airport could provide 375,000 new jobs by 2050 while adding £742 billion to the value of goods and services produced in the UK.
A report in The Guardian claims that Boris Johnson will announce plans to convert Heathrow Airport into a residential area.
Preferring sites to the east of London over expanding the existing Heathrow site in the west, the report says the city's mayor will accept that "Heathrow would have no future as an airport under their plans."
David Cameron, Boris Johnson and Heathrow Airport bosses all agree that UK airport capacity needs to significantly increase but do not share an opinion on where it should take place.
The Mayor of London will announce his chosen hub airport options for submission to the Davies Commission on the future of aviation capacity in the UK this morning.
According to a report in The Telegraph, Boris Johnson will reveal that he believes a new airport on the Isle of Grain in North Kent has the "greatest potential."
The move could put the mayor on a collision course with David Cameron, who removed Transport Secretary Justine Greening from her position last year after she campaigned against expansion at Heathrow.