In recent years, Michael Douglas has battled stage-four throat cancer.
In June, the Hollywood actor hit the headlines when he said his battle against throat cancer was caused by performing by a sexually transmitted disease.
The 68-year-old claimed his stage-four cancer was contracted through the human papilloma virus during oral sex.
Read: Michael Douglas blames his throat cancer on HPV virus
Read: Douglas and Zeta Jones separate
Welsh actress Catherine Zeta Jones and her husband Michael Douglas are "taking some time apart", her publicist has said.
The couple married 13 years ago and have two children, Dylan and Carys, together.
Earlier this year, Jones - who shot to fame in the early 1990s playing Mariette Larkin in The Darling Buds Of May - checked into a clinic for treatment of a two bipolar disorder.
She has previously said of the illness: "There is no need to suffer silently and there is no shame in seeking help."
Read: Catherine Zeta Jones and Michael Douglas 'separate'
Catherine Zeta Jones and Michael Douglas are "taking some time apart to evaluate and work on their marriage", a statement released by her publicist said.