Around 100 conservative hardliners shouted "death to America" and threw eggs and shoes at Iran's President Rouhani's official car on his return from New York after his historic phone call with President Obama, according to Reuters.
The slogan has been widely used since the 1979 Islamic Revolution.
Hundreds of Iranians cheered President Hassan Rouhani on his return from his United Nations visit in New York.
But after his historic phone call with US President Barack Obama a smaller number of hardliners shouted "Death to America" and threw eggs and shoes at his official car leaving the airport, Iranian media reported.
President Obama said he believed that a deal could be reached with Iran but urged caution given the historical "deep mistrust" between the countries.
"We're mindful of all the challenges ahead," Obama said.
"The very fact that this was the first communication between an American and Iranian president since 1979 underscores the deep mistrust between our countries but it also indicates the prospect of moving beyond that difficult history."
"The test will be meaningful, transparent and verifiable actions."