Nick Bonnie, 30, collapsed at a nightclub in Manchester in the early hours of Saturday.
Mr Cameron said: "This is a tragic death. We've seen too many of these".
When asked if the Government has a grip on its drugs policy, he said: "The focus of Government has quite rightly been on education...and treatment".
He added that he disagreed with the Chief Constable of Durham's call for some drugs to be decriminalised as "it would make them more available and lead to more problems".
The parents of charity worker Nick Bonnie who died after collapsing at a Manchester nightclub have paid tribute to their son. The 30-year-old's death is suspected to be drugs related.
Andy and Pauline Bonnie told ITV News' Dan Rivers he "touched so many old and young".
Mrs Bonnie, a drugs rehabilitation worker, also appealed for people to avoid illegal substances.
"If anybody's thinking or offered or believes that it's a good thing to take drugs it isn't.
"Drugs destroy people's lives, the impact it's having for our family is a permanent one, and I don't think we'll never get over it...he was a special boy."
The Prince's Trust has paid tribute to one of its managers who died after collapsing at a music event in Greater Manchester on Saturday.
Police are investigating the suspected drugs related death of 30-year-old Nick Bonnie who had been at the Warehouse Project in Trafford when he was taken ill.
– A SPOKESPERSON FROM THE PRINCE’S TRUST
We are deeply saddened to hear this news. Nick was a talented and valued colleague and he will be missed. Our thoughts go out to his family and friends at this difficult time.
The parents of Nick Bonnie, who died after collapsing at a nightclub in Greater Manchester at the weekend, said he had a "big heart, big personality and the most infectious smile in Stroud".
A statement from Pauline and Andy Bonnie said their son was a keen sportsman and Liverpool fan who had found the "true vocation of his life" in working for The Prince's Trust, where he had "helped many young people" before going on to raise funds and the (charity's) profile in a later role.
"Our lives and all those who were blessed to share a part in his life, are broken," they said. "Our life will never be the same without Nick and he will never be forgotten."
Police are investigating the suspected drugs death of a man who collapsed at a nightclub in Greater Manchester.
Nick Bonnie, 30, fell ill at a dance event at the Warehouse Project in Trafford and died on Saturday morning.
At least 15 other club-goers were admitted to hospital feeling unwell after taking a controlled drug, ITV Granada has reported.
Mr Bonnie, from Stroud in Gloucestershire, worked as a manager for The Prince's Trust.
The charity said it was "deeply saddened" by his death and described him as "a talented and valued colleague (who) will be missed”.
Police in Manchester are trying to find out more about a "particularly bad batch of drugs" after a man died and five people were admitted to hospital at a music venue.
Police were called to Manchester Royal Infirmary at about 4.30am today after the death of a 30-year-old man who had collapsed at the Warehouse Project in Trafford, Manchester.
The five other people were admitted to hospital feeling unwell after taking a "controlled drug" at the same venue, Greater Manchester Police said.
Detective inspector Aaron Duggan said: "It is possible that there may a particularly bad batch of drugs out there in the community and that is a concern to us."