More than a thousand striking teachers have marched through Birmingham over changes to their pay and pensions.
They are unhappy about government plans to introduce performance related pay.
They also say a 1% pay rise this year and previous pay freezes have cut their wages and they are being asked to pay more into their pensions.
Thousands of teachers are taking part in a one-day strike today in a continued row over pay, pensions and working conditions. The walkout will affect schools in the East of England, the East Midlands, West Midlands and Yorkshire and Humberside.
Click below for the schools affected in:
Michael Gove is "dismissing" the concerns of teachers "as if we were children", one school staff member has told Daybreak.
The education secretary's controversial reforms include performance related pay, which one teacher said "is not really fair" as it is based on the results pupils obtain, not what teachers do in the classroom.
A Department for Education spokeswoman said thousands of teachers striking today was "disappointing" and their actions would "hold back children's education".
She said: "It is disappointing that the NUT and NASUWT are striking over the Government's measures to allow heads to pay good teachers more."
"All strikes will do is disrupt parents' lives, hold back children's education and damage the reputation of the profession," the spokeswoman added.
The first regional walkout took place in the North West on June 27, and further strikes are expected to take place on October 17 in the North East, South East, South West and London.
Plans for a national one-day walkout before Christmas have also been announced by the two unions.
England's two biggest teaching unions NASUWT and the National Union of Teachers, who organised today's strike, have called for "a change in the government's attitude to education".
– Chris Keates, NASUWT General Secretary
The overwhelming majority of teachers in four regions will be on strike today.
Strike action is a last resort, teachers have been left with no choice but to demonstrate their anger and frustration in the face of their genuine concerns being dismissed and trivialised.
– Christine Blower, NUT general secretary
No teacher takes strike action lightly but the intransigence of this Education Sectary has left teachers with no choice.
We cannot stand by and watch our profession be systematically attacked and undermined. There needs to be a change in the Government's attitude to teachers and education.
Thousands of teachers will take part in a one-day strike today in a row over pay, pensions and working conditions.
The walkout is taking place across four regions in England - the East of England, the East Midlands, West Midlands and Yorkshire and Humberside - with tens of thousands of schoolchildren set to be affected.
England's two biggest teaching unions, the National Union of Teachers (NUT) and the NASUWT, have organised the latest wave of regional strikes.
The Government has condemned the move, saying it is "disappointed" the unions have decided to strike.