Italy beat Wales 32-16 at the Millennium Stadium on the opening day of the Rugby League World Cup.
Aidan Guerra scored two tries for the in-form Italians, who beat England in a warm-up match last week.
The defeat leaves Wales on course to meet tournament favourites Australia in the quarter-finals.
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Australia fought back to beat England 28-20 in the opening match of the Rugby League World Cup at the Millennium Stadium.
Underdogs England led 10-0 through tries from Leroy Cudjoe and Ryan Hall, but the visitors dominated the second half of the group match.