Firefighters have been working to help pull people from the wreckage of the commuter train which derailed at 7:20am local time (12:20pm UK time).
At least one rail car from the derailed commuter train is lying near the Hudson River, with rescue workers searching for survivors along the shoreline and waterway.
The National Transport Safety Board has confirmed it is sending a "go team" to New York to investigate the Metro-North train derailment.
A senior Metro-North official says there was no evidence of criminality involved in the New York commuter train derailment, according to NBC News.
The official warned that it was still early in the investigation.
At least 63 people are injured after a train derailed in New York, according to Fire Department officials.
Of them, 11 people are in a critical condition and six in a serious condition.
The Metropolitan Transportation Authority said four or five carriages on the seven-carriages derailed close to the Spuyten Duyvil station in the Bronx, New York.
None of the cars entered the Hudson or Harlem rivers, which are adjacent.
Early reports indicate that four people have died and a further 48 are injured. This figure is expected to change.
The New York Police Department have told NBC News that four people have died and 48 injured in the passenger train crash in New York.
At least two people died after a train derailed in New York City, a police source told CNN.
Around 100 firefighters are responding at the scene.
A major emergency response is underway in the Bronx area of New York City after a train derailed near Spuyten Duyvil station, which is near the Harlem River, NBC News reports.
Local media said five cars have derailed at that there were "multiple injuries."
A witness quoted by AP news agency, Rebecca Schwartz, said some of the carriages of the Metro-North train had been submerged in water, but this was unclear from pictures of the scence.
A passenger train has derailed in the Bronx, New York, according to NBC News.