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Known affectionately to friends and fans as 'Gabo', Garcia Marquez had just returned from hospital after suffering a bout of pneumonia, doctors have said.
Although "One Hundred Years of Solitude" was his most popular creation, other classics from Garcia Marquez included "Autumn of the Patriarch", "Love in the Time of Cholera" and "Chronicle of a Death Foretold".
Colombian President Juan Manuel Santos on death of Gabriel Garcia Marquez has said on Twitter:
'One thousand years of solitude and sadness at the death of the greatest Colombian of all time'
Translation: The Giants never die
The works of Colombian writer Gabriel Garcia Marquez, who died today at his home in Mexico, outsold everything published in Spanish except the Bible.
Marquez was widely considered to be the greatest Spanish-language writer since Miguel de Cervantes in the 17th century, and was often compared to literary giants like Mark Twain and Charles Dickens.
His epic 1967 novel One Hundred Years Of Solitude sold more than 50 million copies in more than 25 languages.
Nobel Laureate Gabriel Garcia Marquez has died at his home in Mexico at the age of 87, a source close to his family has confirmed.
The Colombian writer's magical realist novels and short stories exposed tens of millions of readers to Latin America's passion, superstition, violence and inequality.
Nobel Prize-winning Colombian novelist Gabriel Garcia Marquez has died, Reuters has said.