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A large explosion has hit suburbs in the east of Damascus, ITV News' Dan Rivers reports from the city.
It comes amid a fragile ceasefire that has already seen a number of violations since coming into effect on Saturday.
A temporary halt to the fighting in Syria appears to be largely holding although there is concern by a Russian military build-up in the country, NATO's Secretary General has said.
Jens Stoltenberg told a news conference in Kuwait that the build-up had been "significant" with Russian ground troops, naval forces, and air forces conducting strikes.
He also said there had been some reports of breaches of the temporary truce, although stated that it was "encouraging" that the ceasefire was being respected by most sides.
France said that it had information about fresh attacks on some areas held by moderate rebels.
It called for an immediate meeting of the Syria task force to discuss the violations of the "cessation of hostilities" that came into effect on Friday.
The deal is less binding than a formal ceasefire and does not include the so-called Islamic State or the al-Qaeda linked, al-Nusra.
The Syrian army has retaken the strategic town of Khanasser after a brief incursion by so-called Islamic State, according to sources.
Syrian radio reported on Sunday that Islamic State militants had recaptured the town, which lies on a key government supply route to Aleppo, just a week after the Syrian army had supposedly secured it.
ITV News Correspondent Dan Rivers, who has been reporting from Homs, tweeted that the town had been retaken by regime forces, although said that the road to Aleppo was still not secure.
Khanasser lies about 31 miles south-east of Aleppo.
The US-led coalition carried out operations against Islamic State militants in Syria and Iraq on Sunday.
The coalition's military forces used ground-attack, fighter and remotely-piloted aircraft against the targets.
In Syria, 12 attacks were carried out, and in Iraq, forces also conducted a further 12 strikes supported by Iraq's government.
The targets included gas and oil plants, buildings, vehicles and sniper positions.
The attacks were part of an ongoing campaign to destroy IS targets and limit the group's ability to undertake further terror operations.
Although there is a temporary "cessation of hostilities" in Syria, the internationally-backed agreement does not apply to the militant Islamist groups of Islamic State and al-Nusra.
All aircraft returned to their base safely.
Fighters with the so-called Islamic State have recaptured the Syrian town of Khanasser, according to Syrian radio.
ITV News Correspondent Dan Rivers, reporting from Homs, said the reported fall of the town comes "only a week" since the Syrian army supposedly secured it.
IS fighters originally captured Khanasser on 23 February.
Saudi Arabia has accused Russia and the Syrian government of violating the ceasefire which only came into force one day ago.
Speaking at a news conference in the Saudi capital Riyadh, Foreign Minister Adel al-Jubeir claims the respective air forces violated the cessation of hostilities.
He warned there would be a "plan B" if it became clear that Syrian President Bashar al-Assad's government and its allies were not serious about the truce.
"There are breaches of the truce by the Russian air force and the regime and we are now consulting on this matter with the countries of Syria's support group, and I think that the commitment to the truce will be an important indicator of the seriousness of the Syrian regime," Mr Jubeir said.
Danish Foreign Minister Kristian Jensen, also speaking at the conference, called for a "strong alliance" to put military pressure on the Assad regime to help end the war in Syria.
Latest ITV News reports
Syrian journalist Humam speaks to ITV News, shining a light on life for those still living within the country's devastated borders.
Despite the ceasefire, ITV News has witnessed airstrikes around Homs and seen shelling in Damascus.