Pilots have had to declare an emergency and divert to London after the aircraft's windscreen cracked.
The incident happened after the American Airlines Boeing 767-300 left Zurich bound for New York this morning.
The spokesman said the passengers would be flown on to New York later. It is not yet known why the windscreen cracked.
It is reported that American Airlines flights will resume shortly after issues with their reservations system:
American Airlines have grounded all their flights across America after experiencing problems with their reservation systems, CNBC report.
The company had been experiencing a 'system-wide outage' in their reservation system which had been delaying check-in and flights.
American Airlines have cancelled more than 400 flights in and out of Dallas-Fort Worth airport after several tornadoes ripped through the area.
The airline said it also needed to inspect more than 100 planes that were on the ground during the storm for possible damage.