NFL commissioner Roger Goodell has said it is a "realistic possibility" that there will be a UK-based franchise if the sport continues to grow in Britain.
For the third successive year, the 2016 season will see three games hosted in the capital, with Twickenham joining Wembley in staging International Series fixtures outside of the United States.
Speaking at a press conference in San Francisco ahead of Sunday's Super Bowl 50, Goodell said he expects more games to be taken to London and did not rule out the possibility of a team one day being based on British soil.
"We are considering playing more games in the UK, it's a balancing act with our schedule," he said.
"As you know, we're playing in two stadiums next year and that gives us a little bit more flexibility of how to do that. I believe the future will see more games in the UK.
"As far as a franchise, let's continue to grow, to see that excitement, enthusiasm, passion and support continue to develop. If it does, I think that's a realistic possibility."
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Former British Olympian Lawrence Okoye has signed for the Arizona Cardinals after being waived by NFL rivals the San Francisco 49ers.
Okoye, who still holds the British record for the discus, was let go by San Francisco last week after two seasons trying to establish himself in American football having swapped the track for the gridiron following the 2012 Olympics.
Franchises finalised their 53-man rosters over the weekend but Okoye revealed he has been given a shot by the Cardinals, who, like the Niners, play in the NFC West, and will wind up on their practice squad where he can continue his NFL education.
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Jurors on the murder trial of former New England Patriots player Aaron Hernandez can watch this weekend's Super Bowl - but must walk away if he is mentioned.
The judge at Bristol County Superior Court, Susan Garsh, told the jury they could watch the game but must take precautions to avoid being exposed to information about Hernandez. The Patriots take on the Seattle Seahawks in the showpiece event on Sunday.
Hernandez is charged over the shooting death of semi-professional football player Odin Lloyd in 2013. The trial began on Thursday with opening statements.
Twenty-five-year-old Hernandez, who caught quarterback Tom Brady's last Super Bowl touchdown pass in the Patriots' 2012 loss to the New York Giants, had a $40 million contract with the New England team when he was arrested.
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Michael Sam has become the first openly gay player in a pro-American football team, after he was picked by the St Louis Rams during a draft.
After hearing of the news he would be playing for St Louis, he hugged, kissed and tweeted a picture of himself with his boyfriend to thousands of fans:
Thank you to the St. Louis Rams and the whole city of St. Louis. I'm using every once of this to achieve greatness!! http://t.co/QESdOJVzsw
Houston Texans coach Gary Kubiak has been taken to hospital after collapsing in front of 70,000 fans at halftime during the National Football League home game against the Indianapolis Colts on Sunday, the team said.
The 52-year-old hunched over and dropped to his knees as he was leaving the field. He was taken away on a stretcher and rushed to a Houston hospital.
"He is conscious and his family is with him," the Houston Texans said in a statement.
The team told local reporters he did not have a heart attack.
The Olympic British basketball star and Chicago Bull's player Luol Deng is just one of many athletes who have taken to Twitter to express their delight that Menelik Watson and Laurence Okoye have made the transition to American football.
Just heard @menelikwatson71 has been drafted into the NFL. This kid was a man child at my camps in the UK. Congrats man, very proud of you!
@luoldeng9 Appreciate it. Still remember what you said when I was younger. Trying to do for England in football what you do for basketball