Barack Obama has said he has spoken to David Cameron and Germany chancellor Angela Merkel to prepare for Britain's exit from the European Union.
The US president praised the British prime minister as an "outstanding friend and and partner on the global stage" and said he was confident the UK was "committed to orderly transition out of the EU".
Mr Obama said the Brexit vote "speaks to the growing changes and challenges with globalisation" but added the UK-US special relationship will "endure".
President Obama will travel to Orlando on Thursday to pay his respects to the victims of the gay nightclub shooting.
Buckingham Palace said the Queen had sent a personal message to President Obama, saying: "Prince Philip and I have been shocked by the events in Orlando.
"Our thoughts and prayers are with all those who have been affected."
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