Cristiano Ronaldo hit a late winner to hand 10-man Real Madrid a shock 2-1 win in a fiery El Clasico and end Barcelona's long unbeaten run.
The Portuguese star pounced five minutes from the end of a pulsating La Liga clash at the Nou Camp, just moments after his captain Sergio Ramos had been sent off for the 20th time in his career.
Real had already come from behind with Karim Benzema scoring a superb equaliser to cancel out a Gerard Pique header early in the second half.
The defeat, on what was an emotional occasion for Barca in their first outing since the death of Johan Cruyff, was the Catalan side's first in 40 matches in all competitions.
It also provided a potential twist in the Primera Division title race, with Barca's lead over Atletico Madrid at the top now cut to six points and with Real just another point further behind.
It was Real's first win at the Nou Camp for three years and came in Zinedine Zidane's first Clasico in charge of the team.
Barcelona goalkeeper Marc-Andre ter Stegen may leave the club at the end of the season.Read the full story ›
Arsenal bowed out of the Champions League after goals from Neymar, Luis Suarez and Neymar saw them defeated 5-1 on aggregateRead the full story ›
Barça XI: 1.Ter Stegen 4.Rakitic 5.Sergio 6.Alves 8.Iniesta 9.Suárez 10.Messi 11.Neymar Jr 14.Mascherano 18.Alba 24.Mathieu #FCBLive
Barcelona coach Luis Enrique has hailed Arsenal counterpart Arsene Wenger as a "chosen one"Read the full story ›
Lionel Messi created three goals and scored another as Barcelona warmed up for their Champions League showdown with Arsenal by thrashing Getafe 6-0 at the Nou Camp to equal a club record 12 consecutive La Liga wins.
The Argentinian missed a fourth penalty of the season after Juan Rodriguez's own goal had given the Catalans the lead after just eight minutes, but soon made amends by laying on goals for Munir El Haddadi and Neymar before he got on the scoresheet himself with a brilliant strike from 20 yards.
Messi got his third assist by teeing up Neymar's second after the break and then Arda Turan scored for the second time in three matches with an impressive bicycle kick.
The Champions League clash between Barcelona and Arsenal features two clubs with combined revenues of almost €1billion - the highest ever for a last-16 tie in the competition, according to new figures.
The Deloitte Football Money League, which profiles the highest-earning clubs in world football, puts the two clubs' combined revenue from 2014/15 at €996.3million (£769.9million). Barcelona's revenue is €560.8million (£433.3million) and Arsenal's €435.5million (£336.5million).
The clubs in the last 16 have a total revenue of more than €4.3billion (£3.3billion).
The European tie with the second-highest joint revenue takes place in the Europa League, where Manchester United take on Liverpool in a meeting featuring teams with a combined revenue of €911.3million (£704.2million).
Barcelona defender Gerard Pique has ruled out any chance of him following Pep Guardiola to Manchester City this summer due to his "love" for United.
Guardiola will take over at City this summer and there has already been plenty of speculation about which stars the current Bayern Munich coach might try to bring to the Etihad Stadium.
One player who insists he will not be re-joining his former Barcelona boss though is ex-United defender Pique, who admits he wants to play abroad again before the end of his career but has no intention of representing the blue half of Manchester.
My love for Manchester United is too great for me to sign for City, even though Pep is a great coach.
I'm very happy in Barcelona. United are my second club, but my future is at Barca. I'm very proud to play at Barcelona. I think it's the best club in the world.
I would like to try a different league when I've got a few years to go before retiring. I don't know if it will be Colombia, I'd like that for Shakira, but nobody can predict the future.
Barcelona boss Luis Enrique has rejected claims Gerard Pique picked up a deliberate booking at the Emirates forcing him to miss the second leg at the Nou Camp.
The centre-back cynically fouled Danny Welbeck late on, earning him a caution and a suspension but Enrique has defended Pique.
It wasn't deliberate. Gerard Pique, if you saw the fault (foul), he had to do it, it wasn't deliberate at all.
Everyone who knows about football knows you need a first half like this in order to have a second like the one we had. Arsenal are very good at helping each other collectively and we needed a lot of possession of the ball.
My players individually performed perfectly. But there is nothing decided yet, we will have to perform very well in the (second leg).
Lionel Messi scored two as Barcelona beat Arsenal at the Emirates in the first-leg of their Champions League last 16 tieRead the full story ›