Microsoft founder Bill Gates has said Britain is "stronger, more prosperous and more influential" inside the European Union.
In a letter to The Times the multi-millionaire, who has invested more than a billion dollars in the UK, also warned that after Brexit the UK would be a "significantly less attractive place to do business and invest".
Mr Gates said Britain's EU membership and access to the single market played a role in the decision to place Microsoft's research facilities in Cambridge.
While ultimately a matter for the British people to decide, it is clear to me that if Britain chooses to be outside of Europe, it will be a significantly less attractive place to do business and to invest.
It will be harder to find and recruit the best talent from across the Continent; talent which, in turn, creates jobs for people in the UK.
And, it would be harder to raise the investment needed for public goods such as new medicines and affordable clean energy solutions, for which we need the scale of collaboration, knowledge sharing, and financial backing that the combined strength of the EU provides.
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Microsoft has announced Bill Gates, previously chairman of the board of directors, will assume a new role on the board as founder and technology advisor, in a shake-up that will see Satya Nadella become CEO.
Microsoft said Gates, who founded the company in 1975, will devote more time to the company, supporting Nadella in shaping technology and product direction.
John Thompson, lead independent director for the board of directors, will assume the role of chairman of the board of directors and remain an independent director on the board.
Microsoft has named Satya Nadella as Chief Executive Officer effective immediately, after a five month long search to find Steve Ballmer's successor.
Nadella joined the compnay in 1992 and was charged with overseeing the company’s move to the cloud and the development of the cloud infrastructures that support Bing, Xbox, Office and other services.
“During this time of transformation, there is no better person to lead Microsoft than Satya Nadella,” said Bill Gates, Microsoft’s Founder
Nadella is the third person to lead Microsoft since Bill Gates and Paul Allen founded the company in 1975.
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Microsoft co-founder Bill Gates has admitted that the Control-Alt-Delete key combination was "a mistake" that he hadn't wanted to be used.
"We could have had a single button but the guy who did the IMB keyboard design didn't want to give us our single button," Gates said in a talk at Harvard University. "It was a mistake."
The 57-year-old, now a philanthropist with the Bill and Melinda Gates Foundation, was talking about the early years of Microsoft and the Windows operating system.
His comments begin at 16:30 into the video above.