A family from Bishop Auckland, County Durham, was in torment after the death of a third son who drowned while cooling off in the River Wear.
The body of 16-year-old Colin Dodds was recovered early on Sunday after a major rescue operation, a day after he disappeared while playing with friends.
His older brother Ryan died, aged 14, in July 2009 from multiple organ failure. He was diagnosed with Hirschsprung's disease at birth, a rare condition that affects the bowels.
In 1992, the family lost six-week-old Kenneth after he died from complications caused by his premature birth.
Durham Police confirm they have found the body of missing Bishop Auckland teenager Colin Dodds.
Colin was with two teenagers in the River Wear, in Bishop Auckland, County Durham, when he began to struggle and was unable to reach the river bank.
A joint operation involving police, ambulance, the fire service, the RAF and search and rescue teams was undertaken.
Ambulance crews, the coastguard and the RAF were involved in the search for a missing teenage boy who is believed to have fallen in the River Wear.
The Great North Air Ambulance Service said it was called to the scene at about 5.20pm, a spokesman added:
A major search is under way for a teenage boy who is believed to have fallen in a river.
Emergency services were called earlier today after reports that the boy fell in the River Wear, in Bishop Auckland, County Durham, a Durham Police spokeswoman said.