Jonathan Wyatt, who has a rare inherited eye disease, is one of the participants of a landmark gene therapy to treat blindness.
The 65-year-old barrister said learning he was going blind was a "sledgehammer blow" but there has been "substantial improvement" in his left eye which was treated as part of the trial.
"Now when I watch a football match on the TV, if I look at the screen with my left eye alone, it is as if someone has switched on the floodlights. The green of the pitch is brighter, and the numbers on the shirts are much clearer.
"I am extremely grateful to Professor MacLaren and his splendid team for all the care I received as a “guinea pig” in this groundbreaking research".
Professor Robert MacLaren, who led the gene therapy operations at Oxford Eye Hospital, said his team are "absolutely delighted" with the results so far.
It is still too early to know if the gene therapy treatment will last indefinitely, but we can say that the vision improvements have been maintained for as long as we have been following up the patients, which is two years in one case.
In truth, we did not expect to see such dramatic improvements in visual acuity and so we contacted both patients' home opticians to get current and historical data on their vision in former years, long before the gene therapy trial started.
These readings confirmed exactly what we had seen in our study and provided an independent verification.
Preliminary results from the first six patients taking part in a Phase One trial surprised the Oxford University team.
Preliminary results from the first six patients taking part in a Phase One trial surprised and delighted the Oxford University team.
Although the trial was only designed to test safety and dosages, two men with relatively advanced disease experienced dramatic improvements to their eyesight.
The researchers are now planning a larger Phase II trial that will focus on the therapy's effectiveness.
Groundbreaking gene therapy has restored vision to two men with a rare inherited eye disease who were expected to go blind.
Now, scientists hope early intervention with the surgical treatment will halt progression of the devastating disorder, choroideremia, before patients are robbed of their sight.
It is the first time gene therapy has successfully been applied to the light-sensitive photoreceptors of the retina, the digital camera at the back of the eye.
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People with severe vision impairment due to retinitis pigmentosa are able to read letters and words with the help of a retinal implant, a report by the British Journal of Ophthalmology has shown.
Richard Barrett, who has had the implant for nearly four years, told ITV News he can "perceive certain objects" but not tell the difference between a knife and fork.
Millions of contact lens wearers who fail to clean their lenses correctly are at risk from an eye-devouring amoeba that can cause blindness.Read the full story ›
Rachael Stevens explains how Retinitis Pigmentosa effects her and how she is "extraordinarily excited" by the breakthrough in research.
Professor Robin Ali explains how a study on mice could help treat patients suffering from Retinitis Pigmentosa: