Leave campaigner Nigel Farage has hit back at Bob Geldof in the Remain camp accusing him of "laughing at poor people".
The Ukip leader said Geldof's protest was "absolutely disgusting".
He told ITV News: "It's like rich people laughing at poor people.
"They are multi-millionaires happy to see the fishing industry [in Britain] go to the wall.
"They are there on their big boat effectively laughing at working communities being destroyed."
He also responded to Geldof's claims he had only ever attended one out of 43 meetings on the issue in European parliament saying they were a "waste of time".
"We've surrendered our waters and there's nothing we can do about it. You cannot do anything from within."
The Remain flotilla, led by Sir Bob Geldof, has branded Leave campaigner Nigel Farage a "fraud" who is "no fisherman's friend".
Shouting down a megaphone, Geldof accused Farage of only ever attending one meeting about the issue in European parliament.
He continued: "You're a fraud Nigel and you should go back down the river because you're up one without a canoe."
Sir Bob Geldof tells ITV News some "facts about fishing" as he goes head-to-head with Nigel Farage in an 'In and Out campaign-off' on the Thames.
The Boomtown Rats rocker urged voters not to listen to Remain campaigner Nigel Farage as he branded him a "liar" who "hasn't got a clue what he's doing".
"He's an opportunist of the worst kind," he said.
The In and Out sides of the EU referendum have clashed at a flotilla protest to take back control of British waters on the Thames.
Nigel Farage, who is leading the Leave campaign, was greeted by Remain campaigner Sir Bob Geldof who blasted out the song "In With the In Crowd".
There were also reports the Remain craft had been targeted with water from a fishing boat's hose.
Bob Geldof revealed that he "half expected" the death of his daughter Peaches due to the "way she was carrying on".Read the full story ›
Sir Bob Geldof has defended Band Aid 30 and said despite criticism from artists like Lily Allen, the fundraiser works by creating "noise around it".
Speaking to Good Morning Britain, the Boomtown Rats singer said "of course" there would people who did not like the artists singing, but Band Aid 30 had "a huge cross-section of the biggest selling British artists" and was for a good cause.
Band Aid 30's Do They Know It's Christmas?, which features a host of stars, stormed to the top of the singles chart today.
The charity single, organised once again by Bob Geldof, shifted more than 312,000 copies to make it the year's fastest-selling single, the Official Charts Company said.
But there have been some complaints over the song's content, with some of the lyrics changed to reflect the Ebola crisis in West Africa.
The track, with all proceeds going toward the fight against Ebola in west Africa, has outsold the rest of the top five combined.
The massive sales haul of Band Aid 30, which features Ed Sheeran, Ellie Goulding, One Direction, Rita Ora and Bastille among its star cast, outshines Band Aid 20's first-week sales in 2004 with that version selling 297,000 in its first seven days.
Sir Bob Geldof and Midge Ure have called the announcement that a new version of the Christmas hit Do They Know It's Christmas? is "the worst kept secret this year."
He went on to say that the lyrics to the song will be changed to reflect the Ebola epidemic that the track will be in aid of.
Sir Bob Geldof has told ITV News' Mark Austin he feels he "clearly failed" to help his daughter before a relapse into drugs ended her life.Read the full story ›
Bob Geldof said the UK was a "marriage" that needed to "advance together" at a pro-Scotland union rally in London.
Geldof, who flew in from America for the rally, told the crowds who had gathered in Trafalgar Square that all of the UK is disillusioned with Parliament and Scotland needed to stay to help resolve the issue.
"This argument needs to be had amongst us all. You can't just selfishly resolve it unto yourself by taking an easy opt out clause," he said.
He said the UK was "one of the greatest ideas invented for the modern age" that needed to "advance together".