Police looking for missing Bristol teenager Becky Watts have spent the day searching a house around 3.5 miles from her home.
Neighbours said officers earlier removed a car parked outside.
Becky Watts's uncle told ITV News the family remains hopeful, but are now 'running on empty'.
ITV News reporter Duncan Golestani reports:
Sam Galsworthy, uncle of missing Becky Watts, has spoken about the family's anguish as the search for her continues and they wait for news.Read the full story ›
Police are searching several locations in Bristol including a property in Southmead as they hunt for missing Becky Watts.
Neighbours say the house is occupied by two men, a woman and two young children. Another neighbour has told ITV Westcountry a black car was removed by police from the property.
Police are preparing to use a specialist dog team in another search around the area tomorrow.
Avon and Somerset Police said it is bringing in more police resources to help with the search for missing teenager Becky Watts.
In a statement the police said "a number of locations have now been searched within a 2km radius of Becky’s home address in the St George area of Bristol... but at this stage, no significant items have been identified during these searches."
It added that a "laptop computer which was found a in a local wooded area yesterday, is not related to this missing person investigation".
The two people arrested yesterday are still in police custody but no details about them have been released which is unusual reports ITV News correspondent Rupert Evelyn.
Avon and Somerset police divers have been carrying out open water searches on a lake in St George's Park close to the home of missing teenager Becky Watts.
Police from neighbouring forces have also been drafted in to help look for the 16-year-old. Two people have been arrested in connection with her disappearance.
ITV News reporter Duncan Golastani reports:
Avon and Somerset Police have decided not to release details on the suspects arrested in the case of missing Bristol teenager Becky Watts.
ITV News Correspondent Rupert Evelyn reports:
Police refuse to release details on suspects, where arrests made and what they are being questioned on suspicion of. #BeckyWatts
Becky Watts's family said they are still hopeful the teenager will be found safe but that they "will prepare themselves for the worst."
The police have told us today that two people have been arrested in connection with the disappearance of Becky.
Rebecca has still not been found. We continue to hope that she will be found safe and unharmed but we will prepare ourselves for the worst.
We would like to take this opportunity to thank everyone who has assisted in the search for Becky and for the messages of support.
We continue to work with the police to bring their investigation to a successful conclusion and we would like to ask members of the public to continue to report anything, however small, if they think it may help to find Becky.
Avon and Somerset Police said two people have been arrested in relation to the disappearance of 16-year-old Becky Watts.
This afternoon we have arrested two people in connection with the disappearance of Becky Watts on Thursday 19 February from the St George area of Bristol."
Whilst the two people are being questioned our search for Becky continues unabated. I would like to appeal once again for anyone who might have information about her whereabouts, or anything else that might help us to find her, to call us."
Friends and family of missing Bristol teenager Becky Watts have begun their own search in the Fishponds area of the city.
Avon and Somerset Police have been searching for the teenager since she was reported missing by her family at 4pm on February 20.
The family and friends of missing 16-year-old Becky Watts are due to begin their own search for the teenager later today.
It has been more than a week since Becky was last seen at her house in Crown Hill in St George.
She left home on February 19 with her phone, laptop and tablet computer but did not inform friends or family where she was going, or take extra clothes. Avon and Somerset Police have been searching for the teenager, described as shy, since she was reported missing by her family at 4pm on February 20.
Family and friends will meet in the Fishponds area of Bristol today in an effort to shed light on her whereabouts.
Police divers have been carrying out open water searches on the lake in St George's Park, which is close to Becky's home, while police from neighbouring force areas have also been drafted in to help.
An online campaign for the social media savvy teenager was launched by Avon and Somerset Police earlier this week, using the hashtag #FindBecky.
Police previously said there was "nothing to suggest" that Becky had come to harm, despite fears from Becky's father that she had been attacked.
Becky is described as 5ft 4in and slim, with long, bright red hair and was wearing a dark navy blue Puffa jacket with fabric sleeves.