President Barack Obama has imposed sanctions on Central African Republic's former president, Francois Bozize and four other men linked to violence and human rights abuses in the country, the White House said on Tuesday.
Also sanctioned were Nourredine Adam, a former minister of public security, and Levy Yakete, an "anti-balaka" Christian militia leader. Bozize, Adam and Yakete were blacklisted by the United Nations on Friday.
At least 22 people, including 15 local chiefs and three local members of staff from medical charity Medecins Sans Frontieres, have been killed in an attack on a town in Central African Republic, officials said on Sunday.
Most of the casualties died when an MSF-run clinic in the town was attacked while local chiefs were holding a meeting there.
Children in the Central African Republic need international aid if they are to have any hope of surviving the extreme violence engulfing the Sub-Saharan country, War Child UK have warned.
Atrocities against children as young as three have been carried out, while one in 10 women and girls have been raped, the Children's charity said.
A 12-year-old girl told the charity: "A bullet hit my house while I was in bed. A soldier broke into my house and raped me."
Rob Williams, chief executive of War Child UK, explained: "Every day the crisis in the Central African Republic is worsening, and children are the innocent victims.
"Our survey shows the appalling impact on children and young people, who are losing their parents, their homes and their futures."
The burnt bodies of two Muslim men have been dragged through the streets in the Central African Republic capital Bangui in what the crowd said was a revenge attack for the disappearance of a Christian taxi driver at the hands of Muslim Seleka rebels.
The landlocked former French colony descended into chaos in March after a mostly Muslim rebel coalition, Seleka, marched into the capital, unleashing a wave of killings and looting. That triggered revenge attacks by Christian militia known as "anti-balaka" (anti-machete).
More than a dozen people have died in the Central African Republic as clashes continue following the resignation of the country's president.
ITV News Africa Correspondent Rohit Kachroo reports:
Central African Republic's former president Michel Djotodia travelled to Benin where he will go into exile, government sources in Chad and Benin told Reuters.
Djotodia, who was swept to power last March by northern rebels, resigned along with his prime minister on Friday under intense international pressure after they failed to halt months of inter-religious violence.
A UN migration agency is due to start airlifting thousands of foreign nationals from the Central African Republic, following appeals from neighbouring African countries.
The International Organization for Migration has said the first three IOM charter flights this weekend will repatriate some 800 Chadians from the war torn CAR capital of Bangui to the Chadian capital N’Djamena.
In a statement, the IOM added: "IOM has received requests for assistance from Chad, Niger, Mali, Sudan and the Democratic Republic of the Congo to evacuate thousands of their most vulnerable, stranded nationals.
"The organisation is also working with Senegal, Guinea, Burkina Faso, Côte d’Ivoire, Nigeria and Cameroon to provide post arrival re-integration assistance to migrants evacuated by their governments."
The departure of the Central African Republic's interim president sparked scenes of joy, but fears of a power vacuum in the warring nation.Read the full story ›
Doubts have been raised over who can lead the warring Central African Republic despite widespread celebrations across the country at interim president Michel Djotodia's resignation.
A French diplomatic source said there were "no outstanding candidates" and added: "It is important this transition happens as quickly as possible."
France had repeatedly voiced frustrations with Djotodia's government at the ongoing inter-religious violence after sending hundreds of troops to its former colony last month to support an effort to restore peace.