James Anderson's participation in next month's first Investec Test against Pakistan appears in doubt because of a shoulder injury in his bowling arm.
The England and Wales Cricket Board has confirmed Anderson will definitely miss his scheduled return to action in Lancashire's Specsavers County Championship match against Nottinghamshire at Trent Bridge.
That match begins on July 3, with the four-Test series against Pakistan then getting under way at Lord's only 11 days later.
The ECB has yet to issue an official assessment of Anderson's injury, which has been reported elsewhere as a stress fracture of his right shoulder blade.
Jonny Bairstow and Chris Woakes' career-best Test scores put England in control against Sri Lanka at Lord's as the hosts set a dominant first innings total.
England arguably under-achieved on Thursday's first day of the third Test, as they seek a 3-0 series whitewash, despite the continuation of Bairstow's brilliant form.
But on the resumption, the seventh-wicket pair extended their stand from 52 to 144 to help the hosts to a lunchtime 384 for seven.
Waokes registered his maiden Test half-century before going for 66 leaving Bairstow to shine in an unbeaten 167 as England passed 400 runs before being bowled out for 416.
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James Anderson and Jonny Bairstow were the driving forces as England began their Test summer with an emphatic innings victory inside three days over Sri Lanka at Headingley.
Only bad weather and a maiden half-century from Kusal Mendis remotely threatened to inconvenience England, and Anderson - who finished with a match haul of 10 for 45 - and wicketkeeper Bairstow, with nine catches to add to his 140 runs, were having none of it.
The first of three Tests was wrapped up by an innings and 88 runs, shortly after tea, when Sri Lanka were bowled out for 119 after losing their last seven wickets for 26.
England's bowlers managed only two wickets, both again from James Anderson, on the third morning at Headingley as Sri Lanka tried to hold up their hosts' victory charge in the first Investec Test.
Following on 207 runs behind after being hustled out for 91 by Anderson and Stuart Broad the previous evening, Sri Lanka's lot was once again unenviable to keep England's seamers at bay in difficult conditions.
But a poor weather forecast for Saturday's remaining two sessions, and the jarred left knee which meant Ben Stokes was unlikely to bowl, offered minor respite - and Kusal Mendis rode his luck before rain brought an early lunch, with his team on 77 for two.
England's victory push was set to get under way 15 minutes late, after overnight rain, on day three of the first Test against Sri Lanka at Headingley.
The tourists face an unenviable task, in likely tough conditions again, to have any chance of avoiding defeat over the remaining three days - after being bowled out for 91 on Friday and then following on.
Just two more deliveries were possible on the second evening, with Sri Lanka one for none second time round but needing another 206 just to make England bat again.
A poor forecast on Saturday offered them possible hope of some respite from a rampant home attack, led by James Anderson and Stuart Broad.
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Jonny Bairstow ploughed on past his second Test century, on his home ground at Headingley, to carry England to 298 all out against Sri Lanka.
Bairstow, prolific for much of the past year and especially here for club and now country, finished with 140 before England were bowled out in mid-afternoon on day two of this first Investec Test.
The Yorkshireman dominated stands of 141 for the sixth wicket with Alex Hales and then 56 for the ninth with Steven Finn - the first of those crucial to England's patchy collective performance, after they had stumbled to 83 for five on a rain-shortened opening day.
There was to be no hard-earned maiden century for Hales, though, the opener grinding to a near halt and eventually having to settle for a career-best 86 from 244 balls in almost five and a half hours.
Alastair Cook has revealed Steven Finn, as expected, will start ahead of Jake Ball in England's pace attack for the first Investec Test of the summer.
Ball was given his maiden senior international call-up last week when named in England's 12-man squad to face Sri Lanka at Headingley after impressing with the Lions over the winter and in the early part of the county season.
However, his only hope of making his England bow was to oust Finn, who had niggling injuries over the winter and was reported to have been struggling with his rhythm recently.
Finn, though, played a crucial role in the memorable Test series win in South Africa and he will return to the line-up.
"Steven Finn is going to (play). He has been outstanding when he's been fit for us," Cook confirmed at his press conference.
"It's great to have Jake along, and he's made a big impact this year in county cricket. It's great for the guys who haven't seen too much of him to get to know the guy."