Former Australia captain Steve Smith and Cameron Bancroft will not be appealing against their bans from the game.
Smith was banned along with vice-captain David Warner for their part in ball-tampering during the recent Test series in South Africa.
Batsman Bancroft was banned for nine months following a Cricket Australia investigation which revealed he had used sandpaper to try to alter the condition of the ball during the third Test at Cape Town.
There had been reports of a possible appeal by the players against the bans but Smith has said on Twitter he will not seek to have the sanction reduced.
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Darren Lehmann will leave his post as Australia's head coach after the fourth Test against South Africa, which begins on Friday.
Cricket Australia confirmed his departure, which had appeared unlikely when it was announced earlier in the week that he would remain in his post until the end of his contract.
That was due to run until the end of the 2019 Ashes series in England, but now Lehmann has joined the casualties of Australia's Cape Town debacle.
Cricket Australia announced its chief executive James Sutherland would speak to media at 2.45pm BST in Johannesburg following Lehmann's resignation.
Lehmann had been cleared by a Cricket Australia investigation into the ball-tampering, with Sutherland saying on Tuesday the coach had no prior knowledge of the plot.
At the time, Sutherland said it was "inaccurate" to say Lehmann had resigned, but now he has decided to quit.
"It's the right time to step away," Lehmann said, speaking at a press conference. "I'm ultimately responsible for the culture of the team and I've been thinking about my position for a while.
"Despite telling media yesterday that I'm not resigning, after reviewing Steve and Cameron's hurting it's only fair that I make this decision.
Steve Smith and David Warner have been banned for 12 months over the Australia ball-tampering scandal.
Cameron Bancroft, the batsman who was caught on camera attempting to use tape and dirt to change the condition of the ball during the third Test against South Africa, has been banned for nine months.
The severe punishments were confirmed by Cricket Australia on Wednesday.
CA chairman, David Peever said: "The CA board understands and shares the anger of fans and the broader Australian community about these events.
"They go to the integrity and reputation of Australian Cricket and Australian sport and the penalties must reflect that.
"These are significant penalties for professional players and the board does not impose them lightly. It is hoped that following a period of suspension, the players will be able to return to playing the game they love and eventually rebuild their careers."
Smith and Bancroft gave a press conference after the third day's play, on Saturday, where they admitted a premeditated attempt to tamper with the ball.
CA chief executive James Sutherland announced on Tuesday that the pair, and vice-captain Warner, would be sent home but the investigation concluded that no-one else, including coach Darren Lehmann, was involved.
Matt Renshaw, Glenn Maxwell and Joe Burns have been called up as replacements ahead of the fourth and final Test in Johannesburg.
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Darren Lehmann will continue in his role as head coach of the Australia team after a Cricket Australia investigation found that he had no prior knowledge of the plan to ball tamper during the third Test against South Africa.
CA chief executive James Sutherland said that knowledge of Cameron Bancroft's attempt to manipulate the ball with sticky tape against South Africa in Cape Town was limited to three players - opener Bancroft, captain Steve Smith and vice-captain David Warner.
Sutherland said Tim Paine has been appointed captain of Australia's Test team, and said the three players involved in the ball-tampering case will leave South Africa on Wednesday.
"I want to apologise to all Australians for what took place," Sutherland told a press conference in Johannesburg. "It's about the reputation and integrity of Australian cricket and Australian sport and whether Australians can take pride in their national team.
"The key finding is that prior knowledge of the ball-tampering incident was limited to three players - captain Steve Smith, vice-captain David Warner and Cameron Bancroft.
"The three players on report, we are contemplating significant sanctions, which will reflect the gravity of what has occurred and the damage it has done to the standing of Australian cricket."