Steve Smith and David Warner have been banned for 12 months over the Australia ball-tampering scandal.
Cameron Bancroft, the batsman who was caught on camera attempting to use tape and dirt to change the condition of the ball during the third Test against South Africa, has been banned for nine months.
The severe punishments were confirmed by Cricket Australia on Wednesday.
CA chairman, David Peever said: "The CA board understands and shares the anger of fans and the broader Australian community about these events.
"They go to the integrity and reputation of Australian Cricket and Australian sport and the penalties must reflect that.
"These are significant penalties for professional players and the board does not impose them lightly. It is hoped that following a period of suspension, the players will be able to return to playing the game they love and eventually rebuild their careers."
Smith and Bancroft gave a press conference after the third day's play, on Saturday, where they admitted a premeditated attempt to tamper with the ball.
CA chief executive James Sutherland announced on Tuesday that the pair, and vice-captain Warner, would be sent home but the investigation concluded that no-one else, including coach Darren Lehmann, was involved.
Matt Renshaw, Glenn Maxwell and Joe Burns have been called up as replacements ahead of the fourth and final Test in Johannesburg.