Tottenham look set to have Dele Alli back for the trip to Brighton after he returned to training on Thursday.
Alli has missed Spurs' last two games after suffering a hamstring injury on international duty with England.
Captain Hugo Lloris (thigh) is still out, while boss Mauricio Pochettino is expected to confirm at his press conference whether Toby Alderweireld and Kieran Trippier will return after they were rested at Inter Milan.
The defeat at the San Siro on Tuesday made it three successive losses for Pochettino for the first time in his Spurs reign.
But the Argentinian is taking a balanced view of the team's recent struggles.
"I am so relaxed, so calm. I know football," he said.
"When you win you get praise you sometimes don't deserve. When you lose you get criticised and you need to keep the balance. I accept that situation is going to happen.
"Our objective is to have a very good balance between all the perception and our reality. The group is OK, they are a little bit anxious about winning games. Sometimes it's good to feel pain from the defeat."
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England manager Gareth Southgate believes Alli will be fit for Tottenham's Premier League game with Liverpool at the weekend.
Alli withdrew from the Three Lions squad on Monday ahead of the game with Switzerland after picking up an injury in Saturday's defeat to Spain.
But Southgate believes the 22-year-old will make Spurs' Saturday lunchtime kick-off with Liverpool.
Southgate said at his press conference: "He has just had a minor strain and should be fine for his club at the weekend I would think, but tomorrow's game will come too quickly."
Alli played 90 minutes at Wembley on Saturday and Southgate was impressed with the Tottenham player's contribution.
The manager added: "I thought his performance was good, in terms of his retention of the ball I thought he was improved in that area, his work without the ball has been good over the last six months with us.
"He makes critical forward runs, like everybody else we learned a lot from the game."
Dele Alli has withdrawn from England's squad for the friendly against Switzerland on Tuesday with a "minor muscle strain".
The Tottenham midfielder, who picked up the problem in Saturday's 2-1 Nations League defeat to Spain, will be treated by his club rather than joining the Three Lions at Leicester's King Power Stadium.
Manager Gareth Southgate had already bolstered his squad with Foxes pair Ben Chilwell and Demarai Gray, both of whom could make their debuts at the home ground, and has not called up a replacement for Alli.
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The Tottenham midfielder suffered a minor thigh injury against Tunisia and has been rated as "unlikely" to feature in Nizhny Novgorod by England boss Gareth Southgate.
While Alli took to the field alongside his team-mates on Saturday morning, he participated in the warm-up before carrying out individual drills away from the main group.
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Tottenham's Dele Alli has been forced to withdraw from the England squad due to a hamstring injury.
The 21-year-old shone in Wednesday's memorable Champions League win against Real Madrid, grabbing a brace as Spurs triumphed 3-1 at Wembley.
However, Alli missed Sunday's Premier League encounter against Crystal Palace with a hamstring injury that the Football Association has confirmed will keep him out of this month's internationals.