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The Department of Health is to cut around 650 jobs in a bid to reduce its running costs.
Jobs are expected to start being slashed in the autumn, as the department tries to reduce running costs by 30% over the next five years.
The number of non-senior staff at the department will be cut from 1,800 to 1,200-1,300 by April 2017, ITV News understands.
Three offices in London will be merged to one building at 39 Victoria Street.
Permanent Secretary, Una O'Brien, told ITV News it is "only right" the department takes its "fair share of the efficiency savings".
The Department of Health has an important role leading the health and care system in England to help people live better for longer.
It is only right that the DH should take its fair share of the efficiency savings.
Consolidating our estate on to fewer sites and reducing staff numbers will enable us to deliver efficiencies and provide the most effective service to the country.
The Department of Health said it is aware "urgent action" must be taken to control resistance to antibiotics or "we could face serious problems in years to come"
A spokeswoman said:
That is why the UK is working with WHO and international bodies to support global action.
The development of new antibiotics is key and we are identifying opportunities to promote this.
We have active programmes in all these areas, which together will help us stay one step ahead both nationally and internationally.
In the end the Government won this vote comfortably despite the reservations of some backbenchers and Liberal Democrats. Less comfortable are likely to be the battles ahead over which departments to close in failing hospitals , or even in some which are quite successful.
Labour has failed in a bid to halt plans the Opposition claimed would hand sweeping powers to ministers to close hospitals.The Government saw off an amendment which would have cut Trust Special Administration from the Care Bill, winning a Commons vote 297 to 239, majority 58.
Speaking earlier in the debate, shadow health secretary Andy Burnham compared Health Secretary Jeremy Hunt to a burglar "changing the law to get his way", and warned the Government plans could see an otherwise good hospital closed because of its proximity to a failing one.
MPs will debate a controversial measure that would give ministers the power to close local hospital services in financially failing NHS Trusts.
Labour has said it will vote against the measure, clause 119, when it is debated later this afternoon. Labour whips said on Twitter that the debate is due to take place at 3pm, and the vote will take place at 6pm.
For those asking when #clause119 will be debated - expect debate to start about 3pm with vote/s at 6pm - will provide usual full analysis
Labour's attempts to block clause 119 of the care bill, which would give ministers greater power to close down hospitals, is "irresponsible scaremongering of the worst kind".
A Conservative Party spokesman said:
These claims from Andy Burnham are irresponsible scaremongering of the worst kind - changes to the special administrator regime will simply ensure that patients get safe care, and these powers have only ever been used in extremis twice since 2009, when Labour introduced them in the first place.
This Government is determined to turn round failing hospitals, unlike the Opposition, which didn't confront the sort of under performance and failure we tragically saw at Mid Staffs.