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An image of the devastation caused to a house after a suspected gas explosion shows a huge chunk of the roof has been destroyed.
Officers believe there may have been people inside the house which is in the Riddings area of Alfreton.
Fire and ambulance crews remain on the scene after they were called to an "explosion" just after 7.30am this morning.
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Emergency services are dealing with what is reportedly a gas explosion at a house in Derbyshire.
Police say they were called to Valley View Road, in Riddings just after 7.30am this morning to reports of a house fire.
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A spokeswoman for Derbyshire Fire and Rescue said fire crews have not yet been able to enter the building as it is "too dangerous at present".
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Three men charged with murder following a fatal flat fire in Derbyshire are due to appear in court today.
Peter Eyre, 43, and Anthony Eyre, 21, both from Sandiacre, and Simon Eyre, 24, from Long Eaton, have each been charged with three counts of murder. They are scheduled to appear at Chesterfield Magistrates Court this morning.
Teenage friends Edward Green and Amy Smith, and her six-and-a-half-month-old daughter Ruby-Grace Gaunt, died when the fire broke out at their home in Langley Mill.
Three men have been charged with murder following a fatal flat fire in Langley Mill.
Peter Eyre, 43 and Anthony Eyre, 21, of Central Avenue, Sandiacre and Simon Eyre, 24, of New Tythe Street, Long Eaton have each been charged with three counts of murder.
The father and two sons are due before magistrates in Chesterfield tomorrow.
A 17-year-old, also arrested on suspicion of murder, has been released on bail. He is from Long Eaton.
Amy Smith, 17, her six-and-a-half month old daughter Ruby-Grace Gaunt, and friend Edward Green 17, from Belper, all died when a fire broke put at the flat where Amy and her child lived in North Street, Langley Mill.
Three men arrested on suspicion of murder after a fatal flat fire killed a mother, her baby and a family friend in Derbyshire, were known to at least one of the victims, ITV News understands.
The arrests come after neighbours reported disturbances in the street the day before the blaze which killed Amy Smith, 17, her six-month-old daughter Ruby-Grace Gaunt, and Edward Green, also 17, in Langley Mill.
Police have confirmed a 17-year-old youth rescued from the blaze by neighbours, along with the baby's 18-year-old father Shaun Gaunt, was not among those arrested.
A 17-year-old youth from Long Eaton has been arrested on suspicion of murder along with a 43-year-old and a 21-year-old from Sandiacre. Two of the men are understood to be related to each other.
Police and fire crews are continuing to investigate whether the fire was started deliberately.
The grandfather of a 17-year-old girl who died in a flat fire with her baby daughter in Derbyshire has paid tribute to the "loveable children" as he laid flowers at the scene today.
Amy Smith and her six-month-old daughter Ruby-Grace Gaunt, died in the blaze at her home in Langley Mill along with family friend Edward Green, also 17.
Trevor Smith, who laid flowers at the scene along with his mother and Amy's great grandmother Jean, said: "We're going to miss them all. They were just loveable children.
"I've watched them all growing up and we're going to sadly miss all of them. We're just devastated."
Jean said baby Ruby had suffered from a hole in the heart.
She said: "I think she'd (Amy) be too frightened to jump because of the baby. If she'd have jumped and the baby had got hurt she'd never have forgiven herself."
Three men have been arrested on suspicion of murder after a mother, her baby daughter and a family friend died in a house fire in Derbyshire.
Amy Smith, 17, her six-month-old daughter Ruby-Grace Gaunt, and friend Edward Green, also 17, all died in the blaze at a flat in Langley Mil.
Derbyshire Police said three men - a 17-year-old from Long Eaton along with a 21-year-old and a 43-year-old from Sandiacre, are being questioned in custody after being arrested late last night on suspicion of murder.
Assistant Chief Constable Martyn Bates said: “The cause of the fire is still unknown and the possibility that it was started deliberately is just one of many lines of inquiry we are pursuing at this time.
“These arrests do not mark the end of the investigation, far from it. I would still urge anyone with information to come forward and speak to us.”
A teenager who escaped a house fire that claimed the lives of three youngsters, including a 17-year-old mum and her baby, tried to help his friends escape the blaze but was unable to get to them because of the smoke.
The unnamed teenager's father said: "He tried to get to Ed, who was his best friend, and to the girl and the little girl but the smoke was just too bad".
Police and fire crews are continuing to investigate the cause of the fire in Langley Mill, Derbyshire, which killed Amy Smith, 17, her six month old daughter Ruby Gaunt, and Ed Green, 17.
ITV News correspondent Ben Chapman reports on the latest developments: