Number 10 will fill the vacant positions on its Policy Unit today, with three replacements due.
Number 10 has denied claims that Larry the Downing Street cat is disliked by the Cameron family following speculation in a new book.
While Blair and Brown kept their blows behind closed doors, the current residents of No 10 and 11 are seen brazenly brawling in the street.
The Prime Minister has moved to dispel rumours that he and his family do not get on with Downing Street's resident cat Larry:
I can set everyone's mind at rest in the #SaveLarry campaign. He and I get on purr-fectly well. The kids love him too .
The Prime Minister's spokesman has said the allegations of a cover-up by the Care Quality Commission are "deeply disturbing and appalling."
He added that the Government has taken "strong action" to reform the system.
A 42-year-old man was Tasered after he was seen pointing a knife at his own throat near Downing Street in London, Scotland Yard said.
He was challenged by police just before 9pm yesterday but failed to respond so the electronic weapon was used.
The man had been shouting in the road and appeared to have a knife that he was pointing at his throat.
He suffered a minor head injury when he fell and was taken to hospital as a precaution.
He was later arrested on suspicion of possession of a knife and affray, and remains in custody.
The Number 10 press office has tweeted a picture over the Welsh flag flying over Downing Street to commemorate St David's Day.
– Downing Street spokesman
Downing Street rejects the suggestion that the Cabinet Secretary's review was "botched".
This review correctly concluded that the emails in question were unreliable. The Prime Minister wanted to keep Andrew Mitchell in his job, and was very supportive of him. At the time Andrew Mitchell apologised to the police and chose not to make a complaint to the IPCC - a path which was always available to him.
The Prime Minister takes full responsibility for the way the case was handled and has said repeatedly that what matters now is that the police get to the bottom of this matter.
Conservative MP Andrew Mitchell believes the plebgate CCTV footage recorded at the gates of No 10 Downing Street, with a now disputed email purporting to be an eyewitness account of the event, would have quickly cleared his name if Downing Street had agreed to its release at the time.
Well I think that, had the CCTV been released earlier, together with the email, I think that it would have been discovered quite early on that something was quite seriously wrong with this and I suppose, had that happened, I might still be in Government today.
– Conservative MP Andrew Mitchell
I understand that two of the three poisonous phrases are in it (initial briefing notes), but whether there were two or three or one, whether it was done within one minute or an hour or three hours of the incident at the gate, it is wholly and totally untrue.
Four arrests have been made as part of the Operation Alice investigation into the incident. The row ignited when Mr Mitchell was accused of a heated rant against officers as he left Downing Street on September 19.
In an interview for a second investigation into the plebgate incident by Channel 4's Dispatches, which is due to be broadcast tonight, former chief whip Andrew Mitchell said:
I think Downing Street wanted this to go away. They really wanted me to lie low and let them get on with running the country but I couldn't do that - I couldn't wake up every morning for the rest of my life knowing that I had been stitched up.
Mr Mitchell only asked to see the closed circuit footage of the altercation with police at the main gates of Downing Street on the day he resigned, October 19, but was not shown it for nearly three weeks.
"It was quite a frustrating experience," he added.
Andrew Mitchell has told of his frustration with Downing Street's handling of the plebgate furore claiming it just wanted him to "lie low" rather than clear his name.
The Tory MP, who was forced to quit as chief whip after an intense backlash following claims he called police officers protecting the Prime Minister "plebs", suggested No 10 "wanted this to go away" but said he could not live with knowing he had been "stitched up".
Mr Mitchell believes he would still be in government if footage of the exchanges had been swiftly released. Cabinet Secretary Sir Jeremy Heywood, who viewed the tape in the days after the incident, was sharply criticised by MPs last month over his botched investigation.
The CCTV scenes threw into doubt police claims about what went on when the then Tory enforcer was refused exit through Downing Street's main gates on his bicycle.