The airline easyJet has currently cancelled 145 flights because of a strike by air traffic controllers in France.
The company said that 40 of the cancelled flights on Monday affect UK flights.
It added that it was "disappointed" at what it called "unnecessary strike action" which has affected many passengers and airlines across Europe.
EasyJet said that those meant to be travelling on Monday should check their flight status.
There is industrial action in France affecting some flights today. Pls use our Flight Tracker to check your flight: https://t.co/wzlRrlXQra
The company said it was trying to minimise disruption to passengers caused by the strike.
Although this is outside of our control we would like to apologise to all our customers for any inconvenience and would like to reassure them we are doing all possible to minimise any disruption as a result of the industrial actio
Ryanair has cancelled over 200 flights because of a strike in France by air traffic controllers.
The airline was critical of what it called the "selfish" actions of the ATC unions that led to the cancellation and delays of flights across Europe.
It urged passengers to sign its petition - Keep Europe Skies Open - which calls on the European Commission and European Parliament to protect Europe from what it called "repeated blackmail and disruption" by ATC unions.
1/2 Due to a French ATC strike, we regret a number of flights are cancelled on Monday 21 March. Further info here: https://t.co/zV75hOu700
It says it has contacted all affected customers by email and SMS text message with their options: a full refund, rebooking on to the next available flight or rebooking onto an alternative route.
Budget airline Ryanair has branded the French aviation unions "selfish" following the start of a three-day strike by the country's air traffic controllers.
Hundreds of passengers flying with easyJet, Ryanair and British Airways will face flight cancellations and delays up until Tuesday as a result of the French industrial action in a move that Ryanair deemed "unwarranted" and "grossly unfair".
Passengers travelling from Gatwick, Heathrow and Luton Airport have already been hit by rescheduling after the strike began on Sunday with officials at Gatwick saying that passengers had experienced delays averaging more than 50 minutes.
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UK air passengers are facing major disruption due to a strike by Italian air traffic controllers, with scores of flights cancelled.
The four-hour stoppage tomorrow has led to Ryanair axing 96 flights to and from Italy, including four return services involving flights to and from the UK.
EasyJet has had to cancel up to 60 flights and other UK carriers are also likely to be affected by the action, which lasts from 11.30am to 3.30pm UK time.
The Ryanair cancellations include Manchester-Bologna, Stansted-Ancona, Stansted-Trieste and Liverpool-Pisa.
Ryanair warned that further delays and cancellations are likely and advised passengers to check the status of their flight.