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Phil Jones is part of the Manchester United squad heading to Turkey, but Chris Smalling, Michael Carrick and Memphis Depay will miss the Europa League clash with Fenerbahce.
Jose Mourinho has named a 21-strong group as United continue their Group A campaign in Istanbul on Thursday evening.
Anthony Martial, Tim Fosu-Mensah and Henrikh Mkhitaryan have been included after missing recent squads, while Jones is part of the travelling squad 10 months after his last competitive appearance.
The 24-year-old has recovered from a knee injury but fellow defender Smalling, who has been suffering with a foot complaint recently, has remained in Manchester, as have injured Antonio Valencia and Eric Bailly.
United squad vs Fenerbahce: De Gea, Romero, Johnstone, Blind, Jones, Darmian, Fosu-Mensah, Rojo, Shaw, Fellaini, Herrera, Mkhitaryan, Lingard, Mata, Pogba, Schneiderlin, Young, Ibrahimovic, Martial, Rashford, Rooney.
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