Liverpool striker Christian Benteke is one of a number of big names manager Brendan Rodgers is resting for their Europa League opener in Bordeaux.
The £32.5million summer signing has been left behind on Merseyside along with fellow new arrivals James Milner and Nathaniel Clyne, plus first-choice centre-backs Martin Skrtel and Dejan Lovren and midfielder Lucas Leiva.
That means Mamadou Sakho is set for his first appearance of the season alongside Kolo Toure in what is likely to be a much-changed back four.
Up front, Belgium striker Divock Origi is in line for the first start of his Liverpool career while midfielder Adam Lallana has returned to fitness and is also in contention.
West Ham progressed into the second round of qualifying for this season's Europa League, with Terry Westley hailing their victory over FC Lusitans as "mission accomplished".
The Hammers were 3-0 up heading to Andorra, but any thoughts of a simple evening were expelled when Diafra Sakho, who scored two of those goals, was sent off with less than 15 minutes gone.
Despite their numerical disadvantage, the visitors still sealed a 1-0 win on the night as Elliot Lee grabbed his first senior West Ham goal to complete a 4-0 aggregate victory.
Westley, who was again in charge of the team even though new boss Slaven Bilic travelled with the team and took up a place in the dug-out, was again pleased with how the team performed.
"Mission accomplished, you would say, over the two legs," he said.
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West Ham are currently favourites to occupy the appropriate spot in the Fair Play League, which would see them through to continental competition next season.
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Dynamo Kiev have been ordered to close part of their stadium for next month's Europa League quarter-final after racist behaviour by fans towards Everton players.
The Ukrainian side has also been fined 15,000 euros (£10,950) by UEFA for the setting off of fireworks and for insufficient organisation.
The racist behaviour took place during the 5-2 second-leg win over Everton on March 19.
UEFA has ordered partial closure of the NSK Olimpiyskiy stadium for the first leg of the quarter-final against Fiorentina, to be played in Kiev on April 16.
A UEFA statement read: "The CEDB (UEFA Control, Ethics and Disciplinary Body) has ordered the partial closure of the NSK Olimpiyskiy stadium during the next UEFA competition match which FC Dynamo Kyiv would play as the host club, and in particular, Blocks 43 and 45 of the stadium.
"The Ukrainian club have also been fined 15,000 euros for the setting off of fireworks and the insufficient organisation."