Tottenham left Mousa Dembele, Danny Rose and Kyle Walker at home as they embarked on the 11-hour round trip to Azerbaijan to face Qarabag in the Europa League.
Boss Mauricio Pochettino rested the trio with Sunday's Barclays Premier League clash with Chelsea in mind, while he is also without Erik Lamela (groin), Nabil Bentaleb, Nacer Chadli and Alex Pritchard (all ankle) through injury.
But in-form striker Harry Kane travelled to Baku along with England new boy Dele Alli, who is set to start as he is suspended at the weekend. Spurs will seal their qualification into the knock-out stages with a victory.
Spurs squad: Lloris, Vorm, McGee, Trippier, Alderweireld, Wimmer, Vertonghen, Fazio, Davies, Carter-Vickers, Winks, Dier, Mason, Carroll, Alli, Townsend, Eriksen, Onomah, Son Heung-min, Njie, Kane, Harrison.
Poor Andre Ayew has only been playing in England for a few months and he's already fouled more often than any other player.
The forward was an eye-catching free signing from Marseille over the summer, when Garry Monk persuaded him that Swansea could offer the ideal platform to shine.
Since then, the Ghana international has drawn 37 fouls in 13 Premier League matches, two more than Arsenal's Alexis Sanchez and Southampton's Saido Mane.
Bournemouth defender Simon Francis may suggest that number should be 36, however, after Ayew was awarded a contentious penalty under a challenge from the Cherries defender on Saturday.
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UEFA has ordered Dynamo Kiev to play their next three European home games in an empty stadium as punishment for offences including racist behaviour by fans during the Champions League match against Chelsea last month.
Football's European anti-discrimination body Football Against Racism in Europe (FARE) passed footage to UEFA of an apparent attack on four black fans at the match in Ukraine on October 20th which ended 0-0.
Charges were brought against Dynamo for racist behaviour, crowd disturbances and blocked stairways.
A UEFA statement read: "Dynamo Kiev has been ordered to play their next three UEFA competition matches as host club behind closed doors. The third match is suspended for a probationary period of three years."
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Chelsea captain John Terry is expected to miss Sunday's Premier League clash at Tottenham, with Jose Mourinho blaming a "dangerous" pitch for his ankle problem.
The 34-year-old Blues skipper was taken off on a stretcher during Chelsea's 4-0 Champions League Group G win at Maccabi Tel Aviv on Tuesday night and is likely to face scans to determine the extent of the problem.
"For John to leave the pitch with the result 1-0 I know already that he is in trouble," Mourinho said.
"My medical department is really good. John is a special guy, with a special desire to recover.
"(But) to leave the pitch with the result 1-0, I don't believe too much that he can play (against Spurs)."
Chelsea could also be without Ramires, who was absent from the matchday squad after suffering an injury in training on Monday, when Chelsea tried to preserve the pitch.
"The surface was bad and dangerous," Mourinho added. The pitch was really bad. Ramires slid and had a muscular injury."
Steven Gerrard has confirmed he will train with former club Liverpool next week and is relishing the opportunity to work with Jurgen Klopp.
LA Galaxy midfielder Gerrard has ruled out a return to a playing role with Liverpool and is only training at Melwood during the MLS close season.
The 35-year-old said on BT Sport's Champions League coverage: "I'm going to go in for a couple of weeks and work with Mr Klopp so I'm really looking forward to that, to see what he's about and try and learn a few things from him."
Wayne Rooney and Anthony Martial are available for Manchester United's Champions League match against PSV Eindhoven after recovering from illness and a foot injury respectively.
Phil Jones (ankle) and Ander Herrera (hamstring) are out after being substituted in the 2-1 win over Watford, but midfielder Bastian Schweinsteiger is available despite missing the open part of Tuesday's training session.
Luke Shaw (leg), Michael Carrick (ankle) and Antonio Valencia (foot) are out, but Marouane Fellaini has recovered from a calf injury.
Man United squad: De Gea, Romero, Johnstone, Rojo, Tuanzebe, Smalling, Darmian, McNair, Mata, Blind, Young, Schneiderlin, Powell, Fellaini, Schweinsteiger, Lingard, Depay, Pereira, Rooney, Wilson, Martial.