Giorgio Chiellini has been withdrawn from Italy's squad for their upcoming friendlies against Argentina and England.
The Juventus defender went off injured late in his club's goalless draw with SPAL in Serie A on Saturday.
The 33-year-old is suffering from a thigh problem and the Italian Football Federation (FIGC) announced on Monday he will return to Turin for treatment.
West Ham's Angelo Ogbonna had already been called into the squad on Sunday to provide cover while interim coach Luigi Di Biagio awaited news on Chiellini's condition.
The Azzurri play Argentina at Manchester City's Etihad Stadium on Friday and England at Wembley next Tuesday.
Arsenal striker Danny Welbeck will not face any retrospective action over his alleged dive against AC Milan, Press Association Sport understands.
Welbeck won and converted a dubious penalty in the first half of last Thursday's 3-1 Europa League win that secured Arsenal's place in the quarter-finals.
But UEFA's control, ethics and disciplinary body is satisfied that no further action is required.
UEFA does not have an equivalent rule to the Premier League's regulations on simulation, although its disciplinary body is able to review any incident from a match.
Manchester United have triggered a one-year contract extension clause to retain the services of Ashley Young until the end of next season.
The 32-year-old's deal was due to expire this summer but United have confirmed they have taken up the option of an extra 12 months.
Winger turned full-back Young has been in fine form this season and is back in the England picture ahead of the World Cup.
His inclusion in the latest squad for friendlies against Holland and Italy this month suggests he has a strong chance of going to the World Cup in Russia.
Young has predominantly played as attacking midfielder or forward throughout his career, both centrally and out wide, but he has proved a competent left-back under Jose Mourinho at Old Trafford.
Young joined United from Aston Villa in 2011 and featured in the side that won the Premier League in 2013.
He had a spell out of favour under Louis van Gaal and he was also used sparingly in Mourinho's first campaign in charge last season.
Indeed, he was linked with a big-money move to China in January 2017 but he stayed on to fight for his place at Old Trafford and has become an integral part of Mourinho's side.
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Manchester United will face Tottenham in the semi-finals of the FA Cup.
Chelsea, who beat Leicester after extra time in their quarter-final moments before the draw was made, will face Southampton.
The ties will take place at Wembley over the weekend of April 21-22.
Chelsea booked their place in the semi-finals of the Women's FA Cup with a convincing 3-0 win at Liverpool.
Jonna Andersson opened the scoring after good work from Ramona Bachmann and Drew Spence, with Katie Chapman doubling their advantage on the stroke of half-time with a simple header from Magda Eriksson's free-kick.
Maren Mjelde added a third from the penalty spot in the second half after Gemma Davison was brought down by Reds defender Alex Greenwood to seal their spot in the last four.
The Blues must wait to find out their opponents after the other quarter-final matches between Durham and Everton, Sunderland and Manchester City, and Arsenal and Charlton were postponed due to the weather.
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