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Mesut Ozil has pulled out of Germany's friendly against England with a hamstring problem.
The playmaker has not started Arsenal's last five games with a combination of illness and the hamstring injury, leading to speculation over his future at the Emirates Stadium.
Julian Draxler and Mario Gomez have also been added to the list of those unavailable for Germany, joining keeper Manuel Neuer on the sidelines.
"Neuer has reported injured, it's the same with Ozil and Draxler.
They have minor hamstring injuries but it is too much of a risk to play them.
Gomez has a groin injury."
Germany goalkeeper Manuel Neuer has been ruled out of Wednesday's friendly with England in Dortmund with a calf injury.
Germany boss Joachim Low has called up uncapped Paris St Germain keeper Kevin Trapp as his replacement.
Trapp will compete with Bayer Leverkusen's Bernd Leno and Barcelona's Marc-Andre ter Stegen for the starting spot against the Three Lions.
The fixture comes almost a year to the day Eric Dier's injury-time header sealed a 3-2 England victory in the teams' last friendly in Berlin.
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