Tottenham duo Harry Kane and Harry Winks have withdrawn from the England squad with West Brom midfielder Jake Livermore called up as a replacement.
Kane and Winks both picked up knocks in Spurs' win over Crystal Palace on Sunday, ruling them out of England's friendlies against Germany and Brazil.
Tottenham midfielder Dele Alli had already withdrawn from Gareth Southgate's squad, while there are injury concerns over Gary Cahill and Jordan Henderson.
Livermore, looking to add to his five caps, was the second player added to the squad on Monday after Michael Keane was earlier drafted in to replace Alli.
Winks twisted his ankle against Crystal Palace on Sunday while Kane took a kick to his foot in the same game.
Chelsea defender Gary Cahill, who missed Sunday's win over Manchester United, is due to be assessed by his club before joining up.
Jordan Henderson, who missed Liverpool's win over West Ham with a thigh problem, is due to arrive later in the week.
The Three Lions face Germany on Friday at Wembley and host Brazil at the same venue four days later as Gareth Southgate begins his preparations for the 2018 World Cup.
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Harry Kane took part in Tottenham training on Tuesday morning as he bids to prove his fitness ahead of Wednesday's Champions League clash against Real Madrid.
Kane missed Spurs' defeat at Manchester United on Saturday with a hamstring injury but showed no visible sign of discomfort during a light session at Hotspur Way.
The striker was able to complete some short sprints and basic passing drills while at one point he made a hand gesture appearing to suggest he felt fine.
His return at Wembley would represent a massive boost for Tottenham given Kane has scored five goals in three European games so far.
Erik Lamela was also out with the rest of the squad, with the winger still yet to make an appearance since recovering from a problem with his hips. Lamela has not played since October last year.
Tottenham are level on seven points with Real Madrid in Group H after the sides shared a 1-1 draw at the Santiago Bernabeu earlier this month.
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