National Institute for Health and Care Excellence (Nice) has said that aspirin has become a 'smokescreen' to drugs that reduce blood clots.
Dr Campbell Cowan, chair of the Guideline Development Group, said: "Aspirin has been a little bit of a smokescreen to anticoagulation. We now know it is not safer and it's questionable whether it has any effect at all."
But he said that patients should not stop taking aspirin automatically, but instead make an appointment with their GP to discuss their options.
Seven thousand strokes and 2,000 premature deaths could be avoided if people with an irregular heart rhythm were diagnosed and medicated properly, research suggests, as just half of those who should be on anticoagulants are.
New guidance released has advised doctors to prescribe newer medications rather than using the "smokescreen" of aspirin to treat a common heart condition.
Aspirin had commonly been used to treat atrial fibrillation (AF), a heart rhythm disorder, which affects 1.5% of the population.
The most up-to-date research from the National Institute for Health and Care Excellence (Nice) advises doctors not to prescribe it to AF patients but to use instead anticoagulant drugs which prevent blood clots forming.
Around 200,000 patients in England are currently on aspirin for their AF.
A 2012 Oxford University study, published in The Lancet medical journal, showed that even very low-risk patients benefited from taking cholesterol-lowering statins.
Rory Collins, professor of medicine at Oxford University, worked on the research and said the number of people who could begin taking statins as a result of the new Nice guidance "would be in the the order" of around five million.
He added: "The evidence is very strong that the treatment is cost-effective at these lower levels. Doctors are now in a position to offer statins on this basis."
He said it was up to individual patients to decide whether they wanted to take statins, based on their risk assessment, but Nice's strategy would "reduce the burden on the health service".
The NHS estimates that statins save 7,000 lives a year in the UK.
Millions more people in the UK could be prescribed cholesterol-lowering statins in a bid to prevent more cases of heart disease, heart attacks and strokes.
In draft guidance to the NHS, which is subject to consultation, the National Institute for Health and Care Excellence (Nice) has cut the threshold in half for when doctors should consider prescribing the drugs to patients.
Statins are taken by as many as seven million people in the UK but this could rise dramatically - with experts predicting as many as five million more may have them prescribed.
At present, people with a 20 percent risk of developing cardiovascular disease within 10 years are offered statins, but this is being cut to include all people with a 10 percent risk of developing cardiovascular disease within 10 years.
New research suggests a person's chances of dying from heart disease or cancer is reduced "significantly" by eating nuts, according to a study published in the New England Journal of Medicine.
Dr Charles Fuchs, from the Dana-Farber Cancer Institute in Boston, who led the study said: "The most obvious benefit was a reduction of 29 per cent in deaths from heart disease - the major killer of people in America."
He added that there was also a 11 per cent reduction in the risk of people dying from cancer.
The study also found that nut-eaters tend to be more health conscious than average members of the public.
The findings, drawing on data on almost 120,000 US men and women.