Anj Handa, a friend of Afusat Saliu, who set up the petition on campaigning website Change.org, said:
We have been thwarted at every turn and the Government has failed on so many counts in this case.
The Home Office has failed to stick to its own guidelines on so many counts and have failed Afusat and her daughters miserably.
The Government had a chance to show leadership on the issue of FGM and again have failed miserably.
A mother who fears her two daughters will be subjected to female genital mutilation in her native Nigeria has been told she will be deported tonight.
Afusat Saliu, 31, and her two daughters Bassy, four, and Rashidat, two, were seized by officials on Wednesday and were due to be flown to Lagos but were given an overnight reprieve.
Human rights activists representing Ms Saliu said that she was expected to be deported with her daughters at 7pm from Heathrow airport.
A friend of the mother who, along with her two daughters, faces deportation to Nigeria has thanked supporters who have signed a petition calling for the Home Office to review the evidence.
Anj Handa wrote on Twitter:
Thank you everyone for your RTs and support. I can't get round to thanking you personally, but I want you to know how much it's appreciated.
A Home Office spokeswoman would not confirm if the deportation of Afusat Saliu and her daughters to Nigeria has been delayed, saying it does not comment on individual cases.
Ms Saliu told ITV News she fears her two daughters, four-year-old Bassy and two-year-old Rashidat, will be subjected to female genital mutilation in her native Nigeria if they are deported.
Last night, Virgin boss Sir Richard Branson was flooded with more than a thousand tweets urging him personally to step in to block the flight.
He later tweeted:
Call upon UK & Nigeria governments to do all they can to protect Saliu family & ensure they aren't put at risk of FGM http://t.co/qyGIIqWPLQ
A mother fighting deportation to Nigeria over fears her daughters will face female genital mutilation tells ITV News she feels "let down".Read the full story ›
Speaking to ITV News Yashika Bageerathi said she was all alone and did not know what she was going to do without her family and friends.Read the full story ›
The mother of deported A-level student Yashika Bageerathi said she was worried for her daughter, as she was alone in Mauritius, the country the family fled in 2011.
Yashika arrived in the country alone early this morning. She has spoken to her mother on Skype.
Immigration Minister James Brokenshire wrote to Yashika Bageerathi's local MP David Burrowes outlining the reasons he could not intervene to enable her to stay in the UK to finish her A-levels.
The letter, across three pages, details how Yashika's case was decided, and the factors that prompted the court's decision. Mr Brokenshire says he has personally reviewed the case again and said he "did not consider it appropriate to intervene in this case".
Teenager Yashika Bageerathi has appealed to Home Office ministers and officials to let her come back to the UK to finish her exams.
Speaking via Skype to UK Editor Lucy Manning, from Mauritius, she said she just wanted to complete her A-level exams in the UK.
The A-level student deported to Mauritius last night has told ITV News she is alone and scared in the country her family fled in 2011.
Speaking on Skype, Yashika Bageerathi described what happened to her yesterday, as she was taken from Yarl's Wood detention centre and placed on a flight accompanied by four security guards, after the last-ditch injunction to keep her in the UK failed.