Jack Wilshere will miss the next three months of action due undergoing surgery on his left fibula.
The Arsenal midfielder suffered the injury in August and will be operated on in London later in the week.
Arsenal midfielder Jack Wilshere will require surgery on a hairline fracture in his left leg and is set for several weeks of rehabilitation, Press Association Sport understands.
Manager Arsene Wenger last week confirmed the England international had suffered a "little setback" in his scheduled recovery from the injury sustained in pre-season.
It is understood following further medical examinations, the decision has now been taken that an operation is needed to properly correct the problem and is likely to take place in the next few days.
The news will come as a blow to both the player, who has battled through a string of fitness issues in recent seasons, and club, with forward Danny Welbeck also set for an extended spell on the sidelines until at least Christmas following knee surgery.
Arsene Wenger says midfielder Jack Wilshere has no chance of being involved in England's upcoming qualifiers against San Marino and Switzerland.
Jack Wilshere will miss the start of the new season after suffering a hairline fracture in his ankle.
The Arsenal midfielder is set to be out for between six and eight weeks with the injury.
Arsenal midfielder Jack Wilshere has been fined £40,000 and been severely warned over his behaviour after admitting misconduct.
Wilshere was charged after leading an anti-Spurs song during Arsenal's FA Cup celebrations last month.
England manager Roy Hodgson is hoping Jack Wilshere can put his fitness issues behind him in order to be a key component in the national team.
The Arsenal midfielder showed his talents once again by scoring two in the victory over Slovenia on Sunday, which was a stunning way to end another season marred by injury.
I'm very happy with Jack and the goals he's scored.
In particular, I am happy with his performance. In the second half he was controlling that midfield, it was a performance we've seen from him for a while now.
If we can keep him fit and he can get plenty of Premier League matches and international matches, at his young age we think we've got a good player going forward.
Arsenal midfielder Jack Wilshere has been charged with misconduct following his foul-mouth tirade during his side's FA Cup celebrations.
Wilshere swore about rivals Spurs during a sing-a-long with fans in the middle of the club's open-top bus parade on Sunday.
The FA said in a statement: "It is alleged his conduct in making and/or inciting certain comments during the club’s open bus trophy tour was improper and/or brought the game into disrepute."
Arsenal midfielder Jack Wilshere has apologised for any offence he caused with his expletiveRead the full story ›
Former Arsenal striker Niall Quinn has urges Jack Wilshere to apologise for his expletive laden Spurs chant at the weekendRead the full story ›
Jack Wilshere has mocked Arsenal's north London rivals Tottenham at the club's FA Cup victory paradeRead the full story ›