Joe Hart and Raheem Sterling are set to miss the upcoming England friendlies as Manchester City manager Manuel Pellegrini expects muscle injuries to keep them out for a month.
Roy Hodgson's men travel to world champions Germany next weekend for a mouth-watering friendly that is followed up days later by Holland arriving at Wembley.
However, the 24-man squad named on Thursday for those matches looks set to change after Sterling and Hart were injured as City lost 1-0 at home to rivals Manchester United on Sunday.
Sterling pulled up with a groin complaint midway through the first half and Hart was taken off on a stretcher after half-time, having sustained a calf injury trying to clear up a Martin Demichelis backpass.
"Both of them have muscle injuries," City boss Pellegrini said. "Raheem his groin and Joe in his calf.
"I don't think that a muscle injury you can be fit in one week. Normally three or four weeks."
Hart and Sterling join the likes of Wayne Rooney, Jack Wilshere and Luke Shaw on the sidelines.
Manchester City goalkeeper Joe Hart admits the team's performances have dropped below the minimum required of lateRead the full story ›
Man City have let themselves down this season according to Joe Hart, who found the heavy derby defeat at Man United difficult to swallowRead the full story ›
Manchester City goalkeeper Joe Hart believes Sunday's defeat against Manchester United was one of the worst in his career.
Hart was in between the sticks for the 4-2 drubbing, which leaves the Premier League champions in fourth place in the league.
"That was one of my worst in a Manchester City shirt, definitely," Hart admitted to the Telegraph. "It's hard to take.
“We've won enough of them (derbies) to know how to lose properly, though, and we weren't good enough after the first 15 minutes.
"We let ourselves down and we let our supporters down, but there are six games to go now and they are so big for us.
"It's essential to try and finish third. We've got to get our heads down and win these massive games."
Joe Hart has told his younger international team-mates they have "so much to gain" from playing for England's under-21 team at a tournamentRead the full story ›
Lionel Messi thought Joe Hart's performance on Wednesday night was "phenomenal", Andres Iniesta opted for "outstanding" while Barcelona manager Luis Enrique described Man City's goalkeeper as "incredible".
The Spanish side won 1-0 in the Nou Camp to complete a 3-1 aggregate win over City, but the scoreline would have been much greater but for a string of saves from Hart.
"He was phenomenal, he stopped everything," Messi said on the Barca website. "We have to congratulate him on a great game because he's a fantastic goalkeeper."
Andres Iniesta added: "Hart was key to keeping them in it and was great in one-on-one situations. Outstanding."
Coach Luis Enrique was happy to see his side progress to the quarter-finals of the Champions League, but felt the scoreline did not reflect their dominance - with Hart the main reason.
"The score could have been a rout," he said. "Hart was incredible but we weren't really on towards the end.
JH: 'When Balotelli's on form, he's a great player. We'll concentrate on our game. They have some very good players.' #EC
England goalkeeper Joe Hart has said he has put his name down to take penalties if it comes to it against Italy. But he hopes it won't come down to that.