John Kerry warned of "consequences" after his Russian counterpart made clear Moscow would respect the outcome of Crimea's referendum.
The nuclear agreement between Western powers and Iran was broadly welcomed by politicians, former world leaders and Middle East experts.
As Sergei Lavrov and John Kerry bid for a peaceful resolution to Syria, a former British diplomat says the US is "taking on the master".
US secretary of state John Kerry warned today that the violent acts carried out by Islamist militants in Iraq "show all the warning signs of genocide"
"With the potential of further executions taking place," he said, "and because people are a minority huddled for safety on a mountain top, the United States has made its decision that it must save these lives.
"The world needs to join us in the condemnation of these actions," Mr Kerry added, speaking in the Afghan capital of Kabul.
US Secretary of State John Kerry has arrived in Vienna for talks with foreign ministers about Tehran's nuclear program.
Iran and the six powers- Britain, the US, France, Germany, Russia and China- aim to reach a long-term deal to end the decade-old nuclear standoff by July 20.
US Secretary of State John Kerry has said all of the reports of fraud and irregularities in the second round of the Afghan presidential vote need to be resolved.
The election run-off between the leading contenders, Abdullah Abdullah and Ashraf Ghani, has been deadlocked since the June 14 vote, raising concerns in Washington about a smooth transition of power in Afghanistan just as US troops are withdrawing.
Abdullah Abdullah has declared he was the winner of last month's run-off vote, despite preliminary results showing that Ashraf Ghani won the second round.
US Secretary of State John Kerry will travel to Vienna this weekend to try to break the deadlock in negotiations over Iran's nuclear programme, a senior Western official told Reuters.
The source, who spoke on condition of anonymity, said: "I can tell you that Kerry will be in Vienna this weekend, probably on Saturday."
However, the official added it was unlikely there would be an agreement signed in the near future, given the disagreements between Iran and western nations over Tehran's nuclear programme.
Financial and military aid to Afghanistan would be cut if any party tries to seize power illegally, US Secretary of State John Kerry has said.
The warning comes after Afghan presidential candidate Abdullah Abdullah claimed he was the winner of last month's run-off vote, despite preliminary results showing that Ashraf Ghani won the June 14 second round.
Thousands of Abdullah's supporters gathered in Kabul with some suggesting his camp should declare victory and form a parallel government.
“I have noted reports of protests in Afghanistan and of suggestions of a ‘parallel government’ with the gravest concern,” said Mr Kerry in a statement during a trip to Asia.
US Secretary of State John Kerry has made the highest-level American visit to Egypt since President Abdel-Fattah el-Sissi took office in an attempt by Washington to press the country for more moderate policies.
Kerry said the US government has proposed providing an aid package worth $650 million (£380m) to Egypt and is working with Congress to settle differences over the final amount
Earlier this month, the US quietly agreed to send an estimated $572 million US dollars to Egypt in military and security assistance - widely believed to include Apache attack helicopters- on top of $200 million US dollars in economic aid already delivered.
US secretary of state John Kerry has arrived in Cairo for talks with President Abdel Fattah al-Sisi over Egypt's crackdown on the Muslim Brotherhood and the threat which the conflict in Iraq poses to the Middle East.
Kerry is the highest-ranking US official to visit Egypt since Sisi, the former military leader who toppled Islamist President Mohamed Mursi after mass protests last year, won a May presidential election.
His visit comes a day after an Egyptian court confirmed death sentences against 183 members of Mursi's Muslim Brotherhood, including its leader Mohamed Badie, in a mass trial on charges of violence in which one policeman was killed.
Foreign Secretary William Hague said he hopes today's summit on sexual violence in war will be a "turning point" in the battle against war zone rape.
He responded to US Secretary of State John Kerry on Twittter:
US Secretary of State John Kerry has arrived at a cemetery in Colleville-Sur-Mer to attend a memorial service for American veterans.
US Secretary of State John Kerry has agreed with European and Gulf allied foreign ministers to ramp up support to the moderate Syrian opposition, Reuters has reported.