Several people have been killed after a car bomb exploded near a police station in Damascus, Syrian state television has reported.
Several vehicles were burnt in the blast in the central Bab Touma district, which has now been shut down by security forces as ambulances attend the site.
The explosion took place as President Bashar al Assad was meeting international envoy Lakhdar Brahimi, who has called for a temporary truce in Syria's civil war.
Syrian pro-government TV says an explosion has hit the Old City quarter of Damascus.
Peace envoy Lakhdar Brahimi has met with Syrian President Bashar al-Assad in Damascus as he bids to secure a temporary ceasefire in Syria's bloody civil war, the country's state television has reported.
The international mediator has now met with both sides in the dispute after calling for the conflict to cease during the Islamic Eid al-Adha holiday at the end of this week.
Syria has so far given a guarded response to Mr Brahimi's proposal, suggesting it wants guarantees that rebels would reciprocate any move by Assad's forces.
The UN-Arab League envoy to Syria Lakhdar Brahimi is holding talks with the Syrian foreign minister in Damascus about brokering a ceasefire in the war torn country.
It is not known whether Mr Brahimi will meet President Bashar al-Assad.
On his arrival in the country Brahimi told reporters: "We will talk about the ceasefire and the Syrian issue in general.
"It is important to decrease the violence - we will talk with the government and political parties and civil society about the Syrian issue."
International mediator Lakhdar Brahimi has said talks with Syrian President Bashar al-Assad today were "very serious" and "terribly important" in an effort to end the country's 18-month-old conflict.
UN and Arab League mediator, Lakhdar Brahimi is expected to meet Syrian President Bashar al-Assad in Damascus today.
Brahimi arrived in Syria on Thursday, his first trip to the country since taking up his post.
Egyptian president Mohamed Mursi has told Arab ministers that the time has come for change in Syria, report Reuters.
He also added that a quartet proposed by Cairo comprising of Iran, Turkey, Saudi Arabia and Turkey will meet over Syria.
Turkey's prime minister Tayyip Erdogan says the Syrian government has created a "terrorist state", according to the Reuters news agency.
"The regime in Syria has now become a terrorist state," Erdogan told a meeting of his ruling AK Party.
US Secretary of State Hillary Clinton and Chinese Foreign Minister Yang Jiechi vowed goodwill after talks over Syria which had been preceded by criticism from Beijing of her calls for a multilateral solution to the territorial disputes in the South and East China Seas.
The overseas edition of the state-run the People's Daily laid out China's concerns ahead of their meeting, suggesting America was seeking to gain leverage from China's tensions with Japan and South-east Asian countries.
China backs a "political transition" in Syria to end worsening bloodshed after 18 months of unrest, said Mr Yang, while repeating Beijing's opposition to forceful foreign intervention.
Mrs Clinton said it was "no secret" the US was disappointed by the positions of China and Russia on Syria, and she reiterated that the best course of action remained tough UN Security Council action.
United Nations Secretary-General Ban Ki-Moon says that the job that incoming UN-Arab League mediator, Lakhdar Brahimi has been tasked with is "daunting but not insurmountable."
Speaking at the UN assembly, Moon said: