Former cycling doper turned whistleblower Tyler Hamilton described Dr Eufemiano Fuentes as a "one-man Wal-Mart of doping" in his 2012 book The Secret Race, which detailed the use of performance-enhancing drugs in the sport.
Hamilton was among 11 former teammates who testified against Lance Armstrong during the US Anti-Doping Agency's investigation.
In his only UK interview, he gave ITV News his reaction to Armstrong finally confessing.
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The Oprah Winfrey Network said Armstrong did not receive a fee for the interview and was not offered one. But he admitted to losing $75 million dollars when his sponsors departed. "I've lost all future income," he said.
"I don't like thinking about it, but that was a 75 million-dollar day. Gone. And probably never coming back." Armstrong denied claims he attempted to make a payment to United States Anti-Doping Authority (USADA).
He said: "I had no knowledge of that, but I've asked around. I think the claim was 250,000 dollars. That's a lot of money. I would know. That is not true."
When asked how his mother was handling the situation Lance Armstrong said he did not realise how badly she was handling the situation until he saw her.
He said of his mother: "She's a wreck. She is not the type of person who would call me up and say that.
"But my stepfather called me up and said 'your mom is having a really hard time'. I saw my mom, and I thought, 'Oh this woman is a wreck'. It took seeing her to really understand that this has taken a toll on her life."
Lance Armstrong became visibly emotional for the first time in the interview with Oprah when he talked about the moment he had to tell his 13-years-old son Luke not to defend him at school.
He said: "I told Luke, don't defend me any more. Don't.
Courtesy of OWN: Oprah Winfrey Network.
"He's been remarkably calm and mature about this. I said if anybody says anything to you, they are going to see this, some kids or something. Do not defend me. Just say 'hey, my dad said he was sorry'. He said okay.
"He just said look, I love you. You are my dad. This won't change that."
Lance Armstrong was close to tears when he spoke about his having to tell his son not to defend him.
He said: "When this all really started I saw my son defending me and saying 'what you are saying about my dad is not true'. And almost goes to this question of why now.
"That's when I knew I had to tell him. And he had never asked me, he had never said 'dad is this true?' He trusted me.
"At that time I didn't say something, but I knew I had to."
Frankly - this may not be the most popular answer - but I think I deserve it [to be able to compete again], maybe not right now. But if you look at the situation, you look at the culture, and the sport, and you see the punishments. Okay you are trading my story for a sixth month suspension? That's what everybody got. So I got a death penalty (can never compete again). I am not saying that is unfair necessarily, but I am saying it is different.
When asked about whether he was doing the interview with Oprah so that he would be able to race again, Lance Armstrong replied 'hell yes'.
Do I want to compete again. The answer is 'hell yes. I am a competitor. It's what I have done my whole life. I love to train, I love to race, I love to tow the line. I don't expect it to happen. Not the Tour de France, but there are a lot of other things that I could do, but I can't. With this penalty, with this punishment - and I made my bed - but if there was ever window, would I like to run the Chicago marathon when I am 50? I would love to do that, and I can't.