At least a further three people were hospitalised, including a passenger from the Maserati.
A tourist who witnessed the aftermath of the crash told KLAS-TV that the burning taxi looked like a fireball.
More people may be hurt, Sergeant Sheahan said.
It is the latest in a series of violent actions on the tourist corridor since the beginning of the year. Two people were critically wounded in a shooting at a parking garage 6th February, and a tourist was stabbed in an elevator at The Hotel at Mandalay Bay ten days later.
Three people were killed and at least three injured in a gun battle between moving vehicles that ultimately crashed at a busy intersection on the Las Vegas Strip, police have said.
A total of five vehicles were involved in the crash, including a taxi that burst into flames and killed two people around 4.30 am local time, at Flamingo and Las Vegas boulevards, said Sergeant John Sheahan.
People in a Maserati and an SUV were exchanging gunfire before the Maserati hit the taxi, he said.
The Maserati driver, the taxi driver and a taxi passenger were killed.
Driverless cars are being displayed at the world's biggest technology show in Las Vegas.
Google has been trailing its driverless cars for over two years but now the likes of Lexus, Audi and Volvo have produced their versions, bringing the technology one step closer to the roads. Lewis Vaughan Jones reports:
Car makers are all showcasing their latest driverless models in Las Vegas. But will consumers be tempted to let a computer take the wheel?Read the full story ›
Audi's self-parking car uses ultrasound and on-board cameras to perform tricky manoeuvres without the need for human control.
Its 'park assist' system can handle parallel and perpendicular parking and notifies the driver with a dashboard message once it finds a space large enough.
More from CES 2013: Robot allows doctor to check on hospital patients remotely
In the future, patients in hospital may be attended to by robots instead of doctors or nurses. The invention will allow doctors who are not at the hospital to remotely check up on and speak to patients using a videolink.
Other gadgets include smart phone apps that keep track of the user's heart rate and blood pressure.
These are just some of the health-related inventions being showcased at the Consumer Electronics Show (CES) in Las Vegas.
ITV News' correspondent Lewis Vaughan Jones reports:
The future of smart TVs were on display at the Consumer Electronics Show in Las Vegas.
The world's largest consumer technology exhibition has been showcasing the latest in hardware devices. 20,000 products and prototypes have been unveiling, including new 45-inch TVs, new 20-inch tablets and the latest in sound engineering.
Exhibitors at the Consumer Electronics Show in Las Vegas have been showcasing some new products aimed at the younger technology consumers.
Protection for the gadgets many of us already have at home has been popular at the Consumer Electronics Show (CES) in Las Vegas.
With an increasing number of us living in to old age and wanting to stay independent, technology has some novel answers to keep us healthy.Read the full story ›