Leicester boss Claude Puel has admitted he is considering giving Harry Maguire a rest.
The 25-year-old central defender has played 63 matches in all competitions since the beginning of last season, including seven at this summer's World Cup as England reached the semi-finals and finished fourth in the tournament.
"Harry has played a lot of games, but I will analyse it," said Puel ahead of his side's home game against Huddersfield on Saturday.
"To participate in a competition like the World Cup is tough to come back with good focus and freshness and concentration, this is a common thing.
"But if I rest him for this game and we lose, I know I will be criticised.
"But it is important to keep players fresh and we must have a good focus about this. Players need to have some protection."
Ben Chilwell and Demarai Gray received their first England call-ups as Luke Shaw prepares to return to Manchester United after sustaining concussion against Spain.
Gareth Southgate's men started their first ever UEFA Nations League campaign with a 2-1 defeat to La Roja at Wembley on Saturday evening.
England are back in action against Switzerland in a friendly at the King Power Stadium on Tuesday, when Chilwell and Gray could make their debuts at their home ground.
The Leicester duo move up from England Under-21s as left-back Shaw prepares to head back to his club.
The 23-year-old's England return came to a shuddering halt on Saturday, when he was hurt in a collision with Dani Carvajal early in the second half.
A statement from the Football Association read: "Luke Shaw remained at St. George's Park today for further rest and monitoring having sustained concussion against Spain yesterday. He will return to his club tomorrow."
England defender Harry Maguire has signed a new five-year contract with Leicester, the Foxes have announced.
The 25-year-old joined Leicester from Hull in the summer of 2017 and played every minute of their Premier League campaign last season before helping England reach the World Cup semi-finals.
Maguire, who Manchester United were reportedly interested in over the summer, said on Leicester's official website: "Ever since I came to this club, I've always reiterated how good they've been to me.
"They gave me an opportunity to play in the Premier League and built a great platform for me to go and perform at the World Cup, so I thank them a lot. I owe them a lot and I'm looking forward to the future."
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Leicester later signed Freiburg defender Caglar Soyuncu on a five-year contract, subject to a work permit being granted.
The Turkey international has made 15 appearances for his national side.