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Leyton Orient have dismissed manager Alberto Cavasin with immediate effect after a run of six defeats on the spin.
The East London club are only one point from the foot of League Two with 18 points from 18 league fixtures this season.
Head of Fitness Alfredo Vergori and Matteo Festa have also departed the club.
Andy Edwards has been placed in charge of the first team until the end of the season, with Danny Webb promoted into the role of assistant manager.
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14: Red card. Jens Janse is dismissed for bringing down Jake Jervis. Orient down to nine men. 0-1 #LOFC
League Two Leyton Orient followed up the sacking of manager Andy Hessenthaler on Monday by having two men dismissed in the opening 14 minutes on Tuesday against Plymouth.
First James Weir was sent off in the opening minute, before Jens Janse was given his marching orders on his debut.
To add insult, Orient were always 1-0 down thanks to a James Spencer strike.
League Two Leyton Orient have sacked manager Andy Hessenthaler, it has been confirmed.
The former Gillingham boss has left Brisbane Road following his side's 3-1 loss to Notts County on Saturday, which left the club sitting in 14th place in the league.
The club can confirm that Andy Hessenthaler has been relieved of his role as first team manager.
We would like to thank Andy for his service to Leyton Orient since arriving in July 2015 and wish him well in his future career.
Assistant manager Andy Edwards will be assuming Hessenthaler’s duties on an interim basis and will take charge of the team for tomorrow’s night’s Sky Bet League Two home game with Plymouth Argyle.