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Dusan Tadic and Fraser Forster have been passed fit to feature for Southampton against Liverpool, but Ryan Bertrand, Cedric Soares and Shane Long face late assessments before Claude Puel picks his team.
The Southampton manager has also revealed that, regardless of their availability, he has no intention of adapting his team to negate their visitors' significant attacking threat.
Tadic suffered a suspected broken nose playing for Serbia against Wales on Tuesday but is expected to play with a face mask.
Forster, meanwhile, withdrew from the England squad with a slight injury but will start at St Mary's on Saturday, when international team-mate Bertrand could yet also be available.
"Normally (Tadic) will be available for this game," Puel said. "He spoke to the doctor and it's okay for him.
"Cedric has come back into training and Bertrand trained (on Wednesday) along with Long. Normally they are okay.
"We will see this for the last training session before the game. Normally I think all the players are okay. I hope there are no surprises.
"All this is good news, but I don't know if they have a good physical level to be involved in the game against Liverpool. We will see."
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England Under-21 international defender Joe Gomez made a long-awaited return from injury on Sunday, playing 45 minutes for Liverpool in a friendly behind closed doors during the international break.
Having initially played at full-back for the Reds after signing from Charlton Athletic in the summer of 2015, Gomez's debut campaign at the club was curtailed by a cruciate knee ligament injury, suffered just as Jurgen Klopp took over as manager from Brendan Rodgers.
Gomez has since missed 13 months of action after suffering a small setback recently.
Liverpool have utilised recent international breaks to play friendlies against lower-league outfits, with the current absence of top-flight club football giving the opportunity to face Accrington Stanley. The Premier League club ran out 5-0 winners, with Emre Can among the goalscorers.
Though Klopp has not yet been able to play Gomez competitively, he has spoken of his admiration for the defender and admitted he will be given plenty of time to return to full fitness.
It is a long way. He was injured for a long time and now it is a long way back, so there is no rush in it.
We can give him time to come back in the right moment.
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Liverpool striker Danny Ings has returned to the club's Melwood training ground to begin rehabilitation on a season-ending knee injury.
For the second time in just over 12 months the forward has undergone surgery on a knee problem.
The latest issue is not related to the one which kept him out from mid-October until the last game of the season, but is expected to keep him sidelined for seven to nine months.
Liverpool confirmed the 24-year-old was back at their training ground on Wednesday to start the recovery process after undergoing what manager Jurgen Klopp on Friday described as "very positive" surgery on damaged cartilage in London last week.