Lloyds is cutting 1,230 jobs as part of previously announced three-year strategy.
The banking group is cutting jobs in its group operations, retail, marketing and finance divisions and said the losses were not linked to the EU referendum result.
A statement said: "The group's policy is always to use natural turnover and to redeploy people wherever possible to retain their expertise and knowledge within the group.
"Where it is necessary for employees to leave the company, it will look to achieve this by offering voluntary redundancy. Compulsory redundancies will always be a last resort."
Rob MacGregor, national officer of the Unite union, said it was "horrific news" for staff, adding: "Job losses within this taxpayer-backed institution are wholly unacceptable."
The next phase in the government's plan to sell taxpayers' remaining £3.6 billion stake in Lloyds Banking Group is set to begin shortly, Chancellor Philip Hammond has said.
Mr Hammond said the government's 9.1% would be sold through a trading plan to institutional investors following a period of turbulence in the financial markets.
The sale would enable the government to recoup the £20.3 billion used to bail out the bank during the 2008 financial crisis, the chancellor added.
"Returning Lloyds to the private sector is in the interests of the bank, taxpayers and the country as a whole," he said.
"That is why exiting our stake in Lloyds in an orderly way, and at the best possible price, is one of my top priorities as Chancellor."
In July, the Lloyds announced plans to axe 3,000 jobs and close 200 branches as it prepared to cut interest rates following the Brexit vote.
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State-backed Lloyds Banking Group has set aside a further £1.4 billion to take its bill for the mis-selling of payment protection insurance (PPI) to £13.4 billion.
Despite announcing a 38% rise in pre-tax profits for the first half of the year, Lloyds said it was "disappointed" to confirm the extra PPI scandal provision.
Pre-tax profits rose for the first half of 2015 to £1.19 billion, providing a 0.75p dividend for shareholders that amounts to £535 million.
Today's results demonstrate the strong progress we have made in the first half of the year.
We are disappointed to announce further provisions today, but we do so from a position of financial and capital strength.
Lloyds Bank is to cut around 635 jobs in its retail and other divisions.
The cuts, part of reductions announced last October, will hit retail, commercial banking, consumer finance human resources and group operations, with 65 new roles being created.
Lloyds said compulsory redundancies would be a "last resort", but the Unite union said staff who had worked for the company's success had received "all the pain and little of the profits".
Lloyds Banking Group is committed to working through these changes with employees in a careful and sensitive way.
Where it is necessary for employees to leave the company, it will look to achieve this by offering voluntary redundancy. Compulsory redundancies will always be a last resort.
State-backed Lloyds Banking Group has reached a £117 million settlement with the Financial Conduct Authority over the way it handled complaints about payment protection insurance (PPI).
Lloyds apologised to customers affected and said £2.65 million worth of bonuses was being withheld from executives.
The group, which remains nearly 19% owned by the taxpayer after being rescued during the financial crisis, has already set aside £12 billion to cover the cost of compensating those mis-sold PPI.
The penalty to the FCA relates to the handling of complaints over the scandal during the period of March 2012 to May 2013.
The government has sold another £500m of Lloyds Banking Group shares, bringing its overall stake in the bank down to 23%, from 40% in 2009.
Together with the recent dividends payment it brings the total amount recovered for the taxpayer from Lloyds to approximately £8.5bn.
Delighted that we have raised a further £500m for the taxpayer through Lloyds share sales, taking total recovered to approximately £8.5bn